FGFBP1 Antibody

Code CSB-PA623920ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: Fibroblast growth factor-binding protein 1 antibody at 5μg/ml + Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 26 kDa
    Observed band size: 26 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA623920ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA623920ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) FGFBP1 Polyclonal antibody
Uniprot No. Q14512
Target Names FGFBP1
Alternative Names 17 kDa HBGF-binding protein antibody; 17 kDa heparin binding growth factor binding protein antibody; 17 kDa heparin-binding growth factor-binding protein antibody; FGF binding protein 1 antibody; FGF BP antibody; FGF BP1 antibody; FGF-binding protein 1 antibody; FGF-BP antibody; FGF-BP1 antibody; FGFBP antibody; FGFBP-1 antibody; Fgfbp1 antibody; FGFP1_HUMAN antibody; Fibroblast growth factor binding protein 1 precursor antibody; Fibroblast growth factor-binding protein 1 antibody; HBp17 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Fibroblast growth factor-binding protein 1protein (24-234AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Gene References into Functions
  1. These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells. PMID: 27121396
  2. Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension. PMID: 29158353
  3. Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. PMID: 25704764
  4. overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. PMID: 23592278
  5. FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations. PMID: 21436287
  6. Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk. PMID: 20450993
  7. Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair. PMID: 15806171
  8. the FGF interaction domain is contained in the C terminus of FGF-BP1 PMID: 16257968
  9. FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review] PMID: 16324873
  10. The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease. PMID: 16352855
  11. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. PMID: 19411256
  12. KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription. PMID: 19668233

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Subcellular Location Secreted, extracellular space, Cell membrane, Peripheral membrane protein
Protein Families Fibroblast growth factor-binding protein family
Tissue Specificity Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carc
Database Links

HGNC: 19695

OMIM: 607737

KEGG: hsa:9982

STRING: 9606.ENSP00000259988

UniGene: Hs.1690

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