FPGS Antibody

Code CSB-PA23719A0Rb
Size US$166
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, MCF-7 whole cell lysate
    All lanes: FPGS antibody at 3.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 65, 61, 60, 62 kDa
    Observed band size: 65 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FPGS Polyclonal antibody
Uniprot No.
Target Names
FPGS
Alternative Names
EC 6.3.2.17 antibody; FOLC antibody; FOLC_HUMAN antibody; Folylpoly gamma glutamate synthetase antibody; Folylpoly-gamma-glutamate synthetase antibody; Folylpolyglutamate synthase antibody; Folylpolyglutamate synthase mitochondrial antibody; FPGS antibody; mitochondrial antibody; OTTHUMP00000022201 antibody; OTTHUMP00000022202 antibody; Tetrahydrofolate synthase antibody; Tetrahydrofolylpolyglutamate synthase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Folylpolyglutamate synthase, mitochondrial protein (443-546AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FPGS Antibody (Product code: CSB-PA23719A0Rb) is Non-conjugated. For FPGS Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA23719B0Rb FPGS Antibody, HRP conjugated ELISA
FITC CSB-PA23719C0Rb FPGS Antibody, FITC conjugated
Biotin CSB-PA23719D0Rb FPGS Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Gene References into Functions
  1. The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia. PMID: 27036162
  2. Low expression level of FPGS is associated with neuroendocrine lung tumors. PMID: 27064343
  3. Our results revealed a significant difference of overall survival between patients with AA genotype and GA + GG genotype (P<0.05). Our study demonstrated a correlation of the polymorphism of FPGS rs1544105 with MTX treatment efficacy, as well as with overall survival, suggesting it could be used as an effective approach in the prediction of MTX treatment efficacy PMID: 27987364
  4. These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors. PMID: 27387303
  5. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS rs7856096, and STX1B rs4889606. PMID: 26751406
  6. data suggest that FPGS modulation affects global and promoter CpG DNA methylation and expression of several genes involved in important biological pathways PMID: 26895662
  7. FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy. PMID: 26652611
  8. Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk. PMID: 26107232
  9. study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma PMID: 25765001
  10. antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12. PMID: 25229333
  11. Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR, FPGS and TYMS. PMID: 24583629
  12. mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane PMID: 25164808
  13. Polymorphism of FPGS rs1544105 G>A is associated with response to therapy in acute lymphoblastic leukemia. PMID: 24908438
  14. An interaction term, between FPGS rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to methotrexate toxicity in rheumatoid arthritis. PMID: 24447348
  15. High Folylpoly-glutamate synthetase expression is associated with response to therapy in non-small-cell lung cancer. PMID: 22895141
  16. A novel missense mutation 502/490 T>C (L151/101P) in exon 5 of FPGS gene is firstly found in Chinese Han children, and the cytosolic and mitochondrial variants display allelic frequencies of 0.70 % and 0.47 % respectively. PMID: 22809608
  17. The mbr enhanced the expression of FPGS significantly and increased sensitivity of Jurkat cells to MTX efficiently. PMID: 22698741
  18. This is one of the first studies to assess FPGS and GGH genetic variants in relation to plasma homocysteine. PMID: 22018726
  19. The expression of mFPGS was different in A549 cells exposed to different methotrexate enantiomers. PMID: 21418912
  20. intratumor FPGS plays an important role in the efficacy of oral fluoropyrimidine plus LV therapy for colorectal cancer. PMID: 21380490
  21. FPGS gene is proposed as a novel causative gene for cleft lip. PMID: 21093159
  22. Data revealed that high FPGS gene expression, low GGH gene expression and low ABCC1 gene expression in CRC tissues were predictive factors for a high reduced folate level after LV administration. PMID: 19636555
  23. low folylpolyglutamate synthase expression is associated with development of aggressive metastatic behavior of the colorectal cancer PMID: 14676127
  24. Significantly higher expression levels of FPGS were found in mucosa expressing the splice variant DCC342. PMID: 16122883
  25. human mitochondrial FPGS is at least in part strongly associated with the inner mitochondrial membrane PMID: 16169100
  26. Investigation of the molecular regulatory mechanisms directing FPGS gene expression in B precursor-ALL and T-ALL cells. PMID: 16707018
  27. study identified FPGS polymorphisms; results indicate that two of the cytosolic nonsynonymous coding SNPs affected protein expression, in vitro substrate kinetics & folate & antifolate efficacy in cells expressing the polymorphisms PMID: 17875718
  28. Results indicate that hFPGS can catalyze the processive addition of approximately four glutamate residues to DDAH 4PteGlu 1. PMID: 18672898
  29. Aberrant splicing of folylpolyglutamate synthetase is associated with antifolate resistance in leukemia. PMID: 19131550

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Subcellular Location
[Isoform 1]: Mitochondrion inner membrane. Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
Protein Families
Folylpolyglutamate synthase family
Database Links

HGNC: 3824

OMIM: 136510

KEGG: hsa:2356

STRING: 9606.ENSP00000362344

UniGene: Hs.335084

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