FYCO1 Antibody

Datasheet

Code	CSB-PA796500
Size	US$297
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Image	Western blot analysis of extracts from JurKat cells, using FYCO1 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FYCO1 Polyclonal antibody

Uniprot No.

Q9BQS8

Target Names

FYCO1

Alternative Names

CATC2 antibody; CTRCT18 antibody; DKFZp779K1152 antibody; FLJ13335 antibody; FYCO1 antibody; FYCO1_HUMAN antibody; FYVE and coiled coil domain containing 1 antibody; FYVE and coiled coil domain containing protein 1 antibody; FYVE and coiled-coil domain-containing protein 1 antibody; MGC126517 antibody; MGC126519 antibody; RUFY3 antibody; RUN and FYVE domain containing 3 antibody; ZFYVE7 antibody; Zinc finger FYVE domain containing protein 7 antibody; Zinc finger FYVE domain-containing protein 7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from Internal of Human FYCO1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May mediate microtubule plus end-directed vesicle transport.

Gene References into Functions

FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation PMID: 29196475
FYCO1 and MAP1LC3A interact through a novel binding mode that involves Atg8-family proteins PMID: 27246247
Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients. PMID: 28009083
FYCO1 requires a functional LC3A/B-preferring LC3-interacting Region (LIR) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected PMID: 26468287
FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population. PMID: 21636066
We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport. PMID: 20100911
Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors. PMID: 11896456

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Involvement in disease

Cataract 18 (CTRCT18)

Subcellular Location

Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

Tissue Specificity

Expressed in heart and skeletal muscle.

Database Links

HGNC: 14673

OMIM: 607182

KEGG: hsa:79443

STRING: 9606.ENSP00000296137

UniGene: Hs.200227

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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