FYCO1 Antibody

Code CSB-PA866262LA01HU
Size US$166
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  • Western blot
    All lanes: FYCO1 antibody at 2.5µg/ml
    Lane 1: HepG2 whole cell lysate
    Lane 2: Mouse liver tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 167, 44, 169 kDa
    Observed band size: 167 kDa

  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA866262LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FYCO1 Polyclonal antibody
Uniprot No.
Target Names
FYCO1
Alternative Names
CATC2 antibody; CTRCT18 antibody; DKFZp779K1152 antibody; FLJ13335 antibody; FYCO1 antibody; FYCO1_HUMAN antibody; FYVE and coiled coil domain containing 1 antibody; FYVE and coiled coil domain containing protein 1 antibody; FYVE and coiled-coil domain-containing protein 1 antibody; MGC126517 antibody; MGC126519 antibody; RUFY3 antibody; RUN and FYVE domain containing 3 antibody; ZFYVE7 antibody; Zinc finger FYVE domain containing protein 7 antibody; Zinc finger FYVE domain-containing protein 7 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human FYVE and coiled-coil domain-containing protein 1 protein (2-255AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FYCO1 Antibody (Product code: CSB-PA866262LA01HU) is Non-conjugated. For FYCO1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA866262LB01HU FYCO1 Antibody, HRP conjugated ELISA
FITC CSB-PA866262LC01HU FYCO1 Antibody, FITC conjugated
Biotin CSB-PA866262LD01HU FYCO1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
May mediate microtubule plus end-directed vesicle transport.
Gene References into Functions
  1. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation PMID: 29196475
  2. FYCO1 and MAP1LC3A interact through a novel binding mode that involves Atg8-family proteins PMID: 27246247
  3. Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients. PMID: 28009083
  4. FYCO1 requires a functional LC3A/B-preferring LC3-interacting Region (LIR) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected PMID: 26468287
  5. FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population. PMID: 21636066
  6. We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport. PMID: 20100911
  7. Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors. PMID: 11896456

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Involvement in disease
Cataract 18 (CTRCT18)
Subcellular Location
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Tissue Specificity
Expressed in heart and skeletal muscle.
Database Links

HGNC: 14673

OMIM: 607182

KEGG: hsa:79443

STRING: 9606.ENSP00000296137

UniGene: Hs.200227

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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