GABARAPL1 Antibody

Datasheet

Code	CSB-PA861986LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA861986LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA861986LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA861986LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GABARAPL1 Polyclonal antibody

Uniprot No.

Q9H0R8

Target Names

GABARAPL1

Alternative Names

APG8 like antibody; APG8L antibody; ATG8 antibody; ATG8B antibody; ATG8L antibody; Early estrogen regulated protein antibody; Early estrogen-regulated protein antibody; GABA antibody; GABA(A) receptor associated protein like 1 antibody; GABA(A) receptor-associated protein-like 1 antibody; GABARAPL1 a antibody; GABARAPL1 antibody; Gamma aminobutyric acid receptor associated protein like 1 antibody; Gamma-aminobutyric acid receptor-associated protein-like 1 antibody; GBRL1_HUMAN antibody; GEC 1 antibody; GEC-1 antibody; GEC1 antibody; Glandular epithelial cell protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 protein (1-117AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GABARAPL1 Antibody (Product code: CSB-PA861986LA01HU) is Non-conjugated. For GABARAPL1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA861986LB01HU	GABARAPL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA861986LC01HU	GABARAPL1 Antibody, FITC conjugated
Biotin	CSB-PA861986LD01HU	GABARAPL1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

Gene References into Functions

these results indicate that miR-195 regulates cell proliferation, migration, angiogenesis and autophagy of hEPCs by targeting GABARAPL1 PMID: 27623937
Our data demonstrated that a specific decrease of GABARAPL1 expression in breast cancers was associated with both DNA methylation and histone deacetylation and that CREB-1 recruitment on GABARAPL1 PMID: 26474850
Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux PMID: 26050226
GABARAPL1 plays an important role in cell proliferation, invasion, and autophagic flux, as well as in mitochondrial homeostasis and cellular metabolic programs in a breast cancer cell line. PMID: 24879149
Kaplan-Meier survival analysis showed a significant association between low GABARAPL1 expression and poor prognosis of HCC patients. PMID: 24647565
Data demonstrate that HSP90 interacts and protects GABARAPL1 from its degradation by the proteasome. PMID: 22120110
analysis of specific functions of GABARAPL1 [review] PMID: 21597319
Atg8 interacting motif (AIM) in Stbd1 is necessary for GABARAPL1 binding. PMID: 21893048
Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
Gabarapl1 mRNA expression in breast tumours is a good indicator of the risk of recurrence, specifically in lymph nodes positive patients. PMID: 20197771
GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor PMID: 16431922
GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. PMID: 19001416
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. PMID: 19549685

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Subcellular Location

Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm, cytoskeleton. Endoplasmic reticulum. Golgi apparatus.

Protein Families

ATG8 family

Tissue Specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motone

Database Links

HGNC: 4068

OMIM: 607420

KEGG: hsa:23710

STRING: 9606.ENSP00000266458

UniGene: Hs.524250

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Autophagy NOD-like receptor signaling pathway Apelin signaling pathway FoxO signaling pathway Mitophagy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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