GLI2 Antibody

Datasheet
Code CSB-PA009500GA01HU
Product Type Purified Rabbit Anti Human,Mouse PolyClonal Antibody
Size US$685
Uniprot No. P10070
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human GLI2-Specific
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias GLI-Kruppel family member GLI2;Gli2;AW546128 ;
Immunogen Species Homo sapiens (Human)
Target Names GLI2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. This protein localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
HGNC 4318
RGD 1309270
MGI 95728
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Function Functions as transcription regulator in the hedgehog (Hh) pathway
Involvement in disease Holoprosencephaly 9 (HPE9); Culler-Jones syndrome (CJS)
Subcellular Location Nucleus, Cytoplasm, Cell projection, cilium
Protein Families GLI C2H2-type zinc-finger protein family
Tissue Specificity Expressed in breast cancers (at protein level) (PubMed:26565916). Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level) (PubMed:9557682). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (Pu
Database Links

HGNC: 4318

OMIM: 165230

KEGG: hsa:2736

STRING: 9606.ENSP00000354586

UniGene: Hs.111867

Pathway Hedgehog signaling pathway
Hippo signaling pathway

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