GRIA4 Antibody

1. The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID: 29220673
2. Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID: 27443784
3. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
4. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID: 24962026
5. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
6. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID: 22122651
7. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
8. characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID: 12393905
9. Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID: 12497607
10. alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID: 15306133
11. The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID: 15823042
12. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
13. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID: 17233759

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HGNC: 4574

OMIM: 138246

KEGG: hsa:2893

STRING: 9606.ENSP00000282499

UniGene: Hs.503743