GRIN2D Antibody

Datasheet

Code	CSB-PA009915ESR1HU
Size	US$166
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Image	Western blot All lanes: GRIN2D antibody IgG at 3.65μg/ml + HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 144 kDa Observed band size: 144 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GRIN2D Polyclonal antibody

Uniprot No.

O15399

Target Names

GRIN2D

Alternative Names

EB11 antibody; estrogen receptor binding CpG island antibody; GluN2D antibody; Glutamate [NMDA] receptor subunit epsilon 4 antibody; Glutamate [NMDA] receptor subunit epsilon-4 antibody; Glutamate receptor ionotropic antibody; glutamate receptor ionotropic NMDA 2D antibody; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D antibody; Grin2d antibody; N methyl D aspartate receptor subtype 2D antibody; N methyl d aspartate receptor subunit 2D antibody; N-methyl D-aspartate receptor subtype 2D antibody; NMDA 2D antibody; NMDAR2D antibody; NMDE4 antibody; NMDE4_HUMAN antibody; NR2D antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glutamate receptor ionotropic, NMDA 2D protein (330-480AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.

Gene References into Functions

This study found that NMDAR activation, NR2D in particular, is involved in human fetal lung fibroblast proliferation and collagen production through a potential ERK1/2-mediated mechanism. PMID: 28987794
High GRIN2D expression is associated with colorectal cancer. PMID: 26943033
This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals. PMID: 28284346
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers PMID: 27616483
After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics. PMID: 22486492
Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls. PMID: 22833210
In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis. PMID: 21915661
data show that the NMDAR2D was specifically expressed in cultivated keratinocytes PMID: 16328341

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Involvement in disease

Epileptic encephalopathy, early infantile, 46 (EIEE46)

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, NR2D/GRIN2D subfamily

Database Links

HGNC: 4588

OMIM: 602717

KEGG: hsa:2906

STRING: 9606.ENSP00000263269

UniGene: Hs.445015

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Neuronal Markers and Neurodegenerative Diseases Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway cAMP signaling pathway Glutamatergic synapse

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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