GZMB Antibody, FITC conjugated

Datasheet
Code CSB-PA010082LC01HU
Size US$299
Uniprot No. P10144
Protocols ELISA Protocol
Immunogen Recombinant Human Granzyme B protein (21-247AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E), GZMB, CGL1 CSPB CTLA1 GRB
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names GZMB
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location Cytoplasmic granule
Protein Families Peptidase S1 family, Granzyme subfamily
Database Links

HGNC: 4709

OMIM: 123910

KEGG: hsa:3002

STRING: 9606.ENSP00000216341

UniGene: Hs.1051

Pathway Apoptosis
Natural killer cell mediated cytotoxicity

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