HKDC1 Antibody

Code CSB-PA647983LA01HU
Size US$166
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  • Western blot
    All lanes: HKDC1 antibody at 4µg/ml + U87 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 103, 91, 83 kDa
    Observed band size: 103 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA647983LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HKDC1 Polyclonal antibody
Uniprot No.
Target Names
HKDC1
Alternative Names
BC016235 antibody; Hexokinase domain containing 1 antibody; Hexokinase domain-containing protein 1 antibody; Hkdc1 antibody; HKDC1_HUMAN antibody; Putative hexokinase HKDC1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Putative hexokinase HKDC1 protein (129-427AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HKDC1 Antibody (Product code: CSB-PA647983LA01HU) is Non-conjugated. For HKDC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA647983LB01HU HKDC1 Antibody, HRP conjugated ELISA
FITC CSB-PA647983LC01HU HKDC1 Antibody, FITC conjugated
Biotin CSB-PA647983LD01HU HKDC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role.
Gene References into Functions
  1. results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
  2. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
  3. Association of HKDC1 genetic variants with susceptibility to gestational diabetes mellitus. PMID: 27346736
  4. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. PMID: 23903356
Subcellular Location
Mitochondrion membrane; Peripheral membrane protein.
Protein Families
Hexokinase family
Tissue Specificity
Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein lev
Database Links

HGNC: 23302

KEGG: hsa:80201

STRING: 9606.ENSP00000346643

UniGene: Hs.522988

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