HOOK1 Antibody

Datasheet

Code	CSB-PA891526LA01HU
Size	US$166
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Image	Western blot All lanes: HOOK1 antibody at 4μg/ml Lane 1: 293T whole cell lysate Lane 2: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 85, 81 kDa Observed band size: 85 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA891526LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA891526LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) HOOK1 Polyclonal antibody

Uniprot No.

Q9UJC3

Target Names

HOOK1

Alternative Names

A930033L17Rik antibody; Abnormal spermatozoon head shape antibody; azh antibody; h-hook1 antibody; hHK1 antibody; HK1 antibody; HOOK 1 antibody; Hook homolog 1 (Drosophila) antibody; Hook1 antibody; HOOK1_HUMAN antibody; MGC10642 antibody; OTTHUMP00000010548 antibody; OTTMUSP00000008480 antibody; Protein Hook homolog 1 antibody; RP23-80B16.4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein Hook homolog 1 protein (301-600AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The HOOK1 Antibody (Product code: CSB-PA891526LA01HU) is Non-conjugated. For HOOK1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA891526LB01HU	HOOK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA891526LC01HU	HOOK1 Antibody, FITC conjugated
Biotin	CSB-PA891526LD01HU	HOOK1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton.

Gene References into Functions

Hook1 knockdown promoted epithelial-mesenchymal transition and attenuated the sensitivity of hepatocellular carcinoma cells to doxorubicin. In summary, our results indicate that downregulation of Hook1 plays a pivotal role in hepatocellular carcinoma progression via epithelial-mesenchymal transition. Hook1 may be used as a novel marker and therapeutic molecular target in hepatocellular carcinoma PMID: 28718370
Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). PMID: 27365401
SHP2 positively regulates TGFbeta1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. PMID: 25331952
Hook1, a microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into Rab22a-dependent tubules associated with recycling. PMID: 23589492
novel interactions between the microtubule-binding Hook1 and the large family of Rab GTPases also suggest a link between CLN3 function, microtubule cytoskeleton and endocytic membrane trafficking PMID: 15471887
These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Protein Families

Hook family

Database Links

HGNC: 19884

OMIM: 607820

KEGG: hsa:51361

STRING: 9606.ENSP00000360252

UniGene: Hs.378836

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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