HSP90AA1 Antibody

Datasheet
Code CSB-PA557470
Size US$299
Uniprot No. P07900
Image
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A549 cells, 293T cells, mouse brain tissue, K562 cells, Hela cells, Primary antibody: CSB-PA557470(HSP90AA1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
Immunogen Fusion protein of Human HSP90AA1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000
Relevance The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias heat shock protein 90kDa alpha (cytosolic), class A member 1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names HSP90AA1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function
Subcellular Location Nucleus, Cytoplasm, Melanosome, Cell membrane
Protein Families Heat shock protein 90 family
Database Links

HGNC: 5253

OMIM: 140571

KEGG: hsa:3320

STRING: 9606.ENSP00000335153

UniGene: Hs.525600

Pathway Estrogen signaling pathway
PI3K-Akt signaling pathway
Necroptosis
Protein processing in endoplasmic reticulum
Antigen processing and presentation
IL-17 signaling pathway
NOD-like receptor signaling pathway
Th17 cell differentiation

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