Name: IFNGR2 Antibody
Brand: CUSABIO
SKU: CSB-PA011052LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IFNGR2 Polyclonal antibody

Uniprot No.

P38484

Target Names

IFNGR2

Alternative Names

IFNGR2; IFNGT1; Interferon gamma receptor 2; IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma receptor beta-chain; IFN-gamma-R-beta; Interferon gamma transducer 1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Interferon gamma receptor 2 protein (28-205AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The IFNGR2 Antibody (Product code: CSB-PA011052LA01HU) is Non-conjugated. For IFNGR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011052LB01HU	IFNGR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA011052LC01HU	IFNGR2 Antibody, FITC conjugated
Biotin	CSB-PA011052LD01HU	IFNGR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function	Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding.
Gene References into Functions	The study identified an SNP rs9978223 on IFNGR2 gene, associated with increased risk in acute myocardial infarctionpatient from India. PMID: 29434065 In the Title. PMID: 27522156 A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution. PMID: 27599734 The IFNGR2Q64R polymorphism is correlated with male sex and paranoid schizophrenia in Tunisians. PMID: 27563937 IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK/STAT activation by IFN-gamma could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK/STAT signaling in patient cells, whereas adding galectins impaired these processes in control cells. PMID: 27499022 Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency. PMID: 25592983 The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe. PMID: 25708927 This is the first study that shows an association between SNPs and liver fibrosis in the general population PMID: 25301852 We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma receptor (IFN-gammaR)2 deficiency PMID: 23963039 IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17(+) cells from both healthy and IFN-gammaR2-deficient CD4(+) T cells. PMID: 23459074 IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease. PMID: 23161749 JAK2 is a critical factor that stabilizes IFN-gammaR2 surface expression in Th17 cells from AMS patients, making them sensitive to IFN-gamma. PMID: 22219326 We conclude that the polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals PMID: 22057826 Data indicate that perturbation of IFN-gammaR2 internalization by mutating the LI(255-256) motif induces a timely coordinated activation of IFN-gamma/STAT1 signaling pathways that leads to the apoptosis of T cells. PMID: 20709103 HBV viraemia appears to have substantial heritability and polymorphisms in the IFNGR2 gene appear to be associated with the variability of viraemia. PMID: 20980339 between the two IFNg receptors, IFNgR2 expression appears to be the deciding factor that controls the way in which target cells physiologically respond to IFNgamma. PMID: 20587546 These results suggesedt that the microglial and oligodendrocytic expression levels of IFN-gamma-R2 are much lower than the astrocytic expression levels in the human CNS. PMID: 20554027 The existence of abnormalities in the intracellular processing and protein expression of the IFN-gamma R2 in response to specific stimuli such as IFN-gamma and M. leprae membrane proteins in adherent cells of LL patients. PMID: 20039824 Results show that the discovery of the anti-Bax activity of the cytoplasmic domain of IFNgammaR2 may shed new light on the mechanism of how cell death is controlled by IFNgamma and Bax. PMID: 19657228 Phages displaying fusion proteins with full-length PNRC2 (proline-rich nuclear receptor co-regulatory protein 2), already shown to be a cofactor for other nuclear receptors, and with a polypeptide of the bHLH corepressor TLE1 bound to AF-1. PMID: 14651967 In pre eclampsia IFN-gamma R2 protein expression mimicked that in early placental development. PMID: 15585559 Higher frequency of +874T interferon gamma, both in hetero and in homozygosis and mostly whether simultaneous, plays a role in predisposing to gluten intolerance and an increased risk for coeliac disease. PMID: 15979955 Two IFN-gammaR2 chains interact through species-specific determinants in their extracellular domains. Finally, these determinants also participate in the interaction of IFN-gammaR2 with IFN-gammaR1. PMID: 16467876 interferon-gamma (IFN-gamma) receptor PMID: 16467883 Single Nucleotide Polymorphisms in IFNGR2 is associated with gastric cancer PMID: 16885196 Therefore, our results suggest that the interaction between Sirt2 and 14-3-3 beta/gamma is a novel mechanism for the negative regulation of p53 beside the well-characterized Mdm2-mediated repression. PMID: 18249187 No significant change was demonstrated in the expression of IFN-gamma receptor beta-chain on surfaces of alveolar macrophages acquired from smokers. PMID: 19269302 Show More Hide All
Involvement in disease	Immunodeficiency 28 (IMD28)
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm.
Protein Families	Type II cytokine receptor family
Tissue Specificity	Expressed in T-cells (at protein level).
Database Links	HGNC: 5440 OMIM: 147569 KEGG: hsa:3460 STRING: 9606.ENSP00000290219 UniGene: Hs.634632

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Code	CSB-PA011052LA01HU
Size	US$299Purchase it in Cusabio online store (only available for customers from the US)
Image	IHC image of CSB-PA011052LA01HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA011052LA01HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of PC-3 cells with CSB-PA011052LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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IFNGR2 Antibody

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Target Background

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