Recombinant Human Interferon gamma receptor 2(IFNGR2)

1. The study identified an SNP rs9978223 on IFNGR2 gene, associated with increased risk in acute myocardial infarctionpatient from India. PMID: 29434065
2. In the Title. PMID: 27522156
3. A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution. PMID: 27599734
4. The IFNGR2Q64R polymorphism is correlated with male sex and paranoid schizophrenia in Tunisians. PMID: 27563937
5. IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK/STAT activation by IFN-gamma could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK/STAT signaling in patient cells, whereas adding galectins impaired these processes in control cells. PMID: 27499022
6. Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency. PMID: 25592983
7. The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe. PMID: 25708927
8. This is the first study that shows an association between SNPs and liver fibrosis in the general population PMID: 25301852
9. We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma receptor (IFN-gammaR)2 deficiency PMID: 23963039
10. IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17(+) cells from both healthy and IFN-gammaR2-deficient CD4(+) T cells. PMID: 23459074
11. IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease. PMID: 23161749
12. JAK2 is a critical factor that stabilizes IFN-gammaR2 surface expression in Th17 cells from AMS patients, making them sensitive to IFN-gamma. PMID: 22219326
13. We conclude that the polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals PMID: 22057826
14. Data indicate that perturbation of IFN-gammaR2 internalization by mutating the LI(255-256) motif induces a timely coordinated activation of IFN-gamma/STAT1 signaling pathways that leads to the apoptosis of T cells. PMID: 20709103
15. HBV viraemia appears to have substantial heritability and polymorphisms in the IFNGR2 gene appear to be associated with the variability of viraemia. PMID: 20980339
16. between the two IFNg receptors, IFNgR2 expression appears to be the deciding factor that controls the way in which target cells physiologically respond to IFNgamma. PMID: 20587546
17. These results suggesedt that the microglial and oligodendrocytic expression levels of IFN-gamma-R2 are much lower than the astrocytic expression levels in the human CNS. PMID: 20554027
18. The existence of abnormalities in the intracellular processing and protein expression of the IFN-gamma R2 in response to specific stimuli such as IFN-gamma and M. leprae membrane proteins in adherent cells of LL patients. PMID: 20039824
19. Results show that the discovery of the anti-Bax activity of the cytoplasmic domain of IFNgammaR2 may shed new light on the mechanism of how cell death is controlled by IFNgamma and Bax. PMID: 19657228
20. Phages displaying fusion proteins with full-length PNRC2 (proline-rich nuclear receptor co-regulatory protein 2), already shown to be a cofactor for other nuclear receptors, and with a polypeptide of the bHLH corepressor TLE1 bound to AF-1. PMID: 14651967
21. In pre eclampsia IFN-gamma R2 protein expression mimicked that in early placental development. PMID: 15585559
22. Higher frequency of +874T interferon gamma, both in hetero and in homozygosis and mostly whether simultaneous, plays a role in predisposing to gluten intolerance and an increased risk for coeliac disease. PMID: 15979955
23. Two IFN-gammaR2 chains interact through species-specific determinants in their extracellular domains. Finally, these determinants also participate in the interaction of IFN-gammaR2 with IFN-gammaR1. PMID: 16467876
24. interferon-gamma (IFN-gamma) receptor PMID: 16467883
25. Single Nucleotide Polymorphisms in IFNGR2 is associated with gastric cancer PMID: 16885196
26. Therefore, our results suggest that the interaction between Sirt2 and 14-3-3 beta/gamma is a novel mechanism for the negative regulation of p53 beside the well-characterized Mdm2-mediated repression. PMID: 18249187
27. No significant change was demonstrated in the expression of IFN-gamma receptor beta-chain on surfaces of alveolar macrophages acquired from smokers. PMID: 19269302

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HGNC: 5440

OMIM: 147569

KEGG: hsa:3460

STRING: 9606.ENSP00000290219

UniGene: Hs.634632