Recombinant Human Interferon gamma receptor 2(IFNGR2)

Code	CSB-CF011052HU
Product Type	Transmembrane Protein
Size	Pls inquiry other sizes
Uniprot No.	P38484
Storage Buffer	Tris-based buffer,50% glycerol
Species	Homo sapiens (Human)
Sequence	APPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
Source	in vitro E.coli expression system
Gene Names	IFNGR2
Protein Names	Recommended name: Interferon gamma receptor 2 Short name= IFN-gamma receptor 2 Short name= IFN-gamma-R2Alternative name(s): Interferon gamma receptor accessory factor 1 Short name= AF-1 Interferon gamma transducer 1
Expression Region	22-337
Tag Info	N-terminal 10xHis-tagged
Protein Description	Full Length of Mature Protein
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function	Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG)
Involvement in disease	Immunodeficiency 28 (IMD28)
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Cytoplasm
Protein Families	Type II cytokine receptor family
Tissue Specificity	Expressed in T-cells (at protein level).
Database Links	HGNC: 5440 OMIM: 147569 KEGG: hsa:3460 STRING: 9606.ENSP00000290219 UniGene: Hs.634632
Pathway	HIF-1 signaling pathway Jak-STAT signaling pathway Necroptosis Natural killer cell mediated cytotoxicity Osteoclast differentiation Th1 and Th2 cell differentiation Th17 cell differentiation

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