IL13 Antibody

Datasheet
Code CSB-PA011590KA01HU
Product Type Polyclonal Antibody
Size US$398
Uniprot No. P35225
Image
  • Western blot analysis of extracts of recombinant rotein using IL13 antibody.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant protein of Human IL13
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Relevance IL-13 is produced by T cells and is important in the TH2 response. IL-13 targets include B cells, eosinophils, fibroblasts, mast cells and macrophages. IL-13 binds specifically to IL-13Rα1 that complexes with IL-4Rα to form the Type II IL-4R. Jak1 and Tyk2 are activated and signal through Stat3 and Stat6. IL-13Rα2 is a different gene product, lacks the intracellular domain, does not complex with IL-4Rα and does not signal. The extracellular domain of IL-13Rα2 is often elevated in diseased states. IL-13 plays key roles in airway hyperresponsiveness (AHR) of allergic asthma and modulates resistance to parasitic organisms.
Storage Buffer Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Affinity purification
Isotype IgG
Alias IL13; ALRH; BHR1; IL-13; MGC116786; MGC116788; MGC116789; P600
Immunogen Species Homo sapiens (Human)
Intended Use For research use only. Not for human, diagnostic or therapeutic use.
Target Names IL13
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cytokine
Involvement in disease Allergic rhinitis (ALRH)
Subcellular Location Secreted
Protein Families IL-4/IL-13 family
Database Links

HGNC: 5973

OMIM: 147683

KEGG: hsa:3596

STRING: 9606.ENSP00000304915

UniGene: Hs.845

Pathway Jak-STAT signaling pathway
Fc epsilon RI signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation

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