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| Code | CSB-PA123096 |
| Product Type | Polyclonal Antibody |
| Former Code(s) | CSB-PA973808 |
| Size | US$297 |
| Uniprot No. | Q13261 |
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| Immunogen | Synthesized peptide derived from internal of Human IL15RA. |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Specificity | The antibody detects endogenous levels of total IL15RA protein. |
| Tested Applications | ELISA,WB;WB:1:500-1:3000 |
| Relevance | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. Anderson D.M., J. Biol. Chem. 270:29862-29869(1995). Yu W., Genome Res. 7:353-358(1997). Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |
| Form | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality | Polyclonal |
| Alias | Interleukin-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; IL15RA; |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol |
| Target Names | IL15RA |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. |
| Subcellular Location | Membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Note=Mainly found associated with the nuclear membrane, SUBCELLULAR LOCATION: Isoform 5: Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein, Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane, SUBCELLULAR LOCATION: Isoform 6: Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein, Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane, SUBCELLULAR LOCATION: Isoform 7: Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein, Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane, SUBCELLULAR LOCATION: Isoform 8: Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein |
| Tissue Specificity | Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15R |
| Database Links |
HGNC: 5978 OMIM: 601070 KEGG: hsa:3601 STRING: 9606.ENSP00000369312 UniGene: Hs.445124 |
| Pathway | Jak-STAT signaling pathway |
IL15RA Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011594GA01HU | IL15RA Antibody | Human | ELISA,WB,IHC |
| CSB-PA011216 | IL15RA Antibody | Human,Rat | WB,ELISA |
| CSB-PA971812 | IL15RA Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA614402ZA01HU | IL15RA Antibody | Homo sapiens | ELISA, WB (ensure identification of antigen) |
IL15RA Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP004551HU | Recombinant Human Interleukin-15 receptor subunit alpha(IL15RA),partial (Active) | Mammalian cell |
| CSB-AP004671HU | Recombinant Human Interleukin-15 & Interleukin-15 receptor subunit alpha(IL15 & IL15RA) (Active) | Mammalian cell |
| CSB-YP614402HU | Recombinant Human Interleukin-15 receptor subunit alpha(IL15RA),partial,Yeast | Yeast |
| CSB-EP614402HU | Recombinant Human Interleukin-15 receptor subunit alpha(IL15RA),partial | E.coli |
| CSB-BP614402HU CSB-MP614402HU |
Recombinant Human Interleukin-15 receptor subunit alpha(IL15RA),partial | Baculovirus Mammalian cell |
IL15RA ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL011594HU | Human Interleukin-15 receptor subunit alpha(IL15RA) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
2-hydroxyisobutyryl-HIST1H4A (K16) Antibody
Applications: ELISA, WB, IF, IP, ChIP
Species Reactivity: Human
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