Igfbp1 Antibody

Code CSB-PA011095LA01MO
Size US$166
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, Mouse heart tissue, Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue
    All lanes: Igfbp1 antibody at 0.6µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 30 kDa
    Observed band size: 50 kDa
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Igfbp1 Polyclonal antibody
Uniprot No.
Target Names
Igfbp1
Alternative Names
Igfbp1 antibody; Igfbp-1 antibody; Insulin-like growth factor-binding protein 1 antibody; IBP-1 antibody; IGF-binding protein 1 antibody; IGFBP-1 antibody
Raised in
Rabbit
Species Reactivity
Mouse, Human
Immunogen
Recombinant Mouse Insulin-like growth factor-binding protein 1 protein (26-272AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Igfbp1 Antibody (Product code: CSB-PA011095LA01MO) is Non-conjugated. For Igfbp1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011095LB01MO Igfbp1 Antibody, HRP conjugated ELISA
FITC CSB-PA011095LC01MO Igfbp1 Antibody, FITC conjugated
Biotin CSB-PA011095LD01MO Igfbp1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Gene References into Functions
  1. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
  2. Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha). PMID: 25869614
  3. serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans PMID: 24152801
  4. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
  5. Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. PMID: 21903863
  6. IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals PMID: 12511596
  7. IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. PMID: 12556485
  8. Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. PMID: 15862298
  9. high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model PMID: 16293667
  10. the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors PMID: 17062566
  11. IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event PMID: 17693389
  12. Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice. PMID: 18827440
  13. the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo. PMID: 19683511

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Subcellular Location
Secreted.
Database Links
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