Itgal Antibody

Datasheet
Code CSB-PA011875LA01MO
See More Details
Size US$299
Uniprot No. P24063
Protocols ELISA Protocol
Immunogen Recombinant Mouse Integrin alpha-L protein (153-325AA)
Raised in Rabbit
Species Reactivity Mouse
Tested Applications ELISA
Relevance Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen 15) (Ly-15) (CD antigen CD11a), Itgal, Lfa-1 Ly-15
Immunogen Species Mus musculus (Mouse)
Research Area Signal Transduction
Target Names Itgal
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Integrin alpha chain family
Tissue Specificity Leukocytes.
Database Links

STRING: 10090.ENSMUSP00000101913

UniGene: Mm.1618

Pathway Regulation of actin cytoskeleton
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Rap1 signaling pathway

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