JAM2 Antibody

Datasheet
Code CSB-PA011936GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P57087
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human JAM2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias junctional adhesion molecule 2;JAM2;C21orf43;CD322;JAM-B;JAMB;PRO245;VE-JAM;VEJAM ;
Immunogen Species Homo sapiens (Human)
Target Names JAM2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
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Function May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
Subcellular Location Cell junction, tight junction, Cell membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily
Tissue Specificity Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
Database Links

HGNC: 14686

OMIM: 606870

KEGG: hsa:58494

STRING: 9606.ENSP00000420419

UniGene: Hs.517227

Pathway Leukocyte transendothelial migration

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