JUND (Ab-255) Antibody

Code CSB-PA987649
Size US$297
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  • Western blot analysis of extracts from HT29 and 293 cells using JunD(Ab-255) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JunD(Ab-255) Antibody
  • Immunofluorescence staining of methanol-fixed Hela cells using JunD(Ab-255) Antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) JUND Polyclonal antibody
Uniprot No.
Target Names
JUND
Alternative Names
Activator protein 1 antibody; AP 1 antibody; AP1 antibody; Jun D antibody; jun D proto oncogene antibody; Jund antibody; JunD FL isoform antibody; JUND_HUMAN antibody; Transcription factor jun D antibody; Transcription factor jun-D antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Peptide sequence around aa. 253~257 (G-E-S-P-P) derived from Human JunD.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
IHC 1:50-1:200
IF 1:100-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor binding AP-1 sites.
Gene References into Functions
  1. Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
  2. In T cells, after serum deprivation HBZ induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia . PMID: 28260789
  3. MiR-663a suppresses proliferation and invasion by targeting AP-1 component JunD in non-small cell lung cancer cells. PMID: 27184257
  4. studies showed that down-regulation of JunD in response to TGF-beta treatment is mediated via the proteasomal degradation pathway. PMID: 27358408
  5. recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1 PMID: 26305372
  6. miR-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha PMID: 25906693
  7. JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD PMID: 25788572
  8. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
  9. BAG3 stabilized JunD mRNA. PMID: 24140207
  10. This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor PMID: 23376981
  11. HTLV-1 bZIP factor(hbz) requires cellular JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat. PMID: 22696638
  12. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs PMID: 22493372
  13. crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer PMID: 22327296
  14. Apoptosis induction by dominant negative JunD is due to induction of growth arrest and DNA damage inducible proteins (GADD) 45 alpha and 45 gamma proteins. PMID: 21734453
  15. JunD mediates, whereas c-Jun modulates, prostaglandin E2 activation of aromatase promoters PMID: 21393445
  16. data indicate that JunD is an inhibitor of RHOH gene expression. PMID: 21473742
  17. These results suggest that the induction of MMP-7 by Tax is regulated by JunD and that MMP-7 could facilitate visceral invasion in adult T-cell leukemia . PMID: 21315773
  18. An alternative model of H ferritin promoter transactivation by c-Jun PMID: 11903046
  19. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH. PMID: 12054733
  20. junD activation by ultraviolet rays plays a role in apoptosis in myeloblastic leukemia ML-1 cells PMID: 12082101
  21. Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat. PMID: 12105216
  22. Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. PMID: 12727841
  23. Menin is important for recruiting an mSin3A-histone deacetylase complex to repress JunD transcriptional activity. PMID: 14559791
  24. Data show that human T-cell leukemia virus type I (HTLV-I) bZIP factor can activate JunD-dependent transcription and that its amino-terminus is required. PMID: 15044019
  25. menin suppresses osteoblast maturation, in part, by inhibiting the differentiation actions of JunD PMID: 15563473
  26. JunD is another ARE regulatory protein for transcriptional activation of the human ferritin H gene and probably other antioxidant genes containing the conserved ARE sequences by which JunD may confer cytoprotection during oxidative stress PMID: 16007120
  27. JunD limits cardiomyocyte hypertrophy and protects the pressure-overloaded heart from cardiac apoptosis PMID: 16129800
  28. Menin's dynamic regulation of histone modifiers with JunD is responsible for PKC theta-synergistic effect on Nur77 expression in T cell PMID: 16264271
  29. Our data suggest that JUND and CLDN4 are critical mediators of the antiproliferative and antiviral effects of type I IFNs and further confirm the functional importance of the DNA-binding domain of Stat2. PMID: 17651017
  30. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult t-cell leukemia. PMID: 18071306
  31. evidence is provided that HBZ/JunD heterodimers interact with Sp1 transcription factors and that activation of hTERT transcription by these heterodimers is mediated through binding sites for Sp1 present in the hTERT promoter. PMID: 18078517
  32. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
  33. JunD overexpression increases production of reactive oxygen species in LNCaP cells in a low androgen environment. PMID: 18386285
  34. JunD is a major determinant of macrophage activity and is associated with glomerulonephritis susceptibility. PMID: 18443593
  35. JunD activation reduces the proliferation of cancer cells. PMID: 18454173
  36. JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function PMID: 18562690
  37. Activated c-Jun is dimerized with JunD in response to adrenomedullin. PMID: 19166930
  38. Data suggest that TGF-beta1 up-regulates angiotensinogen transcription through a mechanism that requires both JunD and HIF-1alpha binding to the AGT core promoter, and that a molecular mechanism links hypoxia signaling and fibrogenic stimuli in the lung. PMID: 19211927
  39. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832

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Subcellular Location
Nucleus.
Protein Families
BZIP family, Jun subfamily
Database Links

HGNC: 6206

OMIM: 165162

KEGG: hsa:3727

STRING: 9606.ENSP00000252818

UniGene: Hs.2780

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