KLRD1 Antibody

Code CSB-PA012470GA01HU
Size US$685
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Product Details

Uniprot No. Q13241
Target Names KLRD1
Alternative Names CD 94 antibody; CD94 antibody; CD94 antigen antibody; Killer cell lectin like receptor subfamily D member 1 antibody; Killer cell lectin-like receptor subfamily D member 1 antibody; KLRD 1 antibody; KLRD1 antibody; KLRD1 protein antibody; KLRD1_HUMAN antibody; KP 43 antibody; KP43 antibody; Natural killer cells antigen CD94 antibody; NK cell receptor antibody; OTTHUMP00000238754 antibody; OTTHUMP00000238755 antibody; OTTHUMP00000238756 antibody; OTTHUMP00000238758 antibody; OTTHUMP00000239093 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human KLRD1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Gene References into Functions
  1. an early response by KLRD1-expressing Natural killer cells may control influenza infection. PMID: 29898768
  2. it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells. PMID: 24975965
  3. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PMID: 24082146
  4. Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function. PMID: 22576308
  5. Loss of CD94 is associated with rheumatoid arthritis. PMID: 22102879
  6. increased expression on natural killer cells in women with recurrent spontaneous abortion after IVIG therapy PMID: 19811464
  7. human CD56(bright) NK cells progress through a continuum of differentiation that ends with a CD94(low)CD56(dim) phenotype. PMID: 19897577
  8. Conservation and variation in human and chimpanzee CD94 genes PMID: 11751968
  9. A critical role of CD94-dependent MHC-I recognition for the regulation of IFN-gamma production and target lysis was demonstrated. PMID: 12149421
  10. TCR specificity dictates CD94/NKG2A expression by CTL. PMID: 12387742
  11. CD94 gene expression is regulated by distal and proximal promoters that transcribe unique initial exons specific to each promoter, resulting in two species of transcripts--the previously described CD94 mRNA and a novel CD94C mRNA. PMID: 14607929
  12. Aberrant expression of natural killer (NK) receptors CD94/NKG2A may have an impact on the magnitude and direction of dendritic cell activation of T cells under pathological conditions, such as chronic hepatitis C virus infection. PMID: 15528343
  13. A CD94 alternatively spliced transcript paired with an NKG2B isoform may contribute to the plasticity of the natural killer cell immunological synapse by insuring an adequate inhibitory signal. PMID: 16237464
  14. Cytolytic activity levels of purified CD94-expressing cells from 7-day cultures with FK506 were much higher than those from 7-day cultures without FK506. PMID: 16378079
  15. results indicate that the SNPs of the inhibitory receptor CD94/NKG2A and its haplotypes, as well as its ligand HLA-E, are associated with Behcet's disease immune systems PMID: 17767552
  16. identified molecular characteristics of an aggressive subset of pediatric patients with AML through a prospective evaluation of CD56+ neural cell adhesion molecule (NCAM) and CD94 expression PMID: 18323797
  17. Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor is described. PMID: 18363778
  18. Under the influence of interleukin-12 stimulation, CD94/NKG2A is transiently inducible in natural killer (NK) cells bearing the homologous CD94/NKG2C-activating receptor, providing a potential negative regulatory feedback mechanism. PMID: 19124726
  19. In this work, the glycan ligands of NKG2D and CD94 for the first time were resolved. PMID: 19303396
  20. NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides. PMID: 19555665

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Subcellular Location Membrane, Single-pass type II membrane protein
Tissue Specificity Natural killer cells.
Database Links

HGNC: 6378

OMIM: 602894

KEGG: hsa:3824

STRING: 9606.ENSP00000338130

UniGene: Hs.562457

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