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Your Good Partner in Biology Research
| Code | CSB-PA012856LB01HU |
| Size | US$299 |
| Uniprot No. | Q9UJU2 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
| Form | Liquid |
| Conjugate | HRP |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha), LEF1 |
| Immunogen Species | Human |
| Research Area | Epigenetics and Nuclear Signaling |
| Target Names | LEF1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
| Subcellular Location | Nucleus |
| Protein Families | TCF/LEF family |
| Tissue Specificity | Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several |
| Database Links |
HGNC: 6551 OMIM: 153245 KEGG: hsa:51176 STRING: 9606.ENSP00000265165 UniGene: Hs.743478 |
| Pathway |
Hippo signaling pathway
Melanogenesis Wnt signaling pathway Adherens junction |
LEF1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA012856GA01HU | LEF1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA020264 | Phospho-LEF1 (S42) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA088510 | LEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA069370 | LEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
LEF1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA012856LA01HU | LEF1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA012856LC01HU | LEF1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA012856LD01HU | LEF1 Antibody, Biotin conjugated | Human | ELISA |
LEF1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012856HU CSB-EP012856HU CSB-BP012856HU CSB-MP012856HU |
Recombinant Human Lymphoid enhancer-binding factor 1(LEF1) | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H2BC (K12) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K5) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
