LEF1

Lymphoid enhancer-binding factor 1 is a protein in humans that is encoded by LEF1 gene. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

LEF1 Antibodies

LEF1 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA012856GA01HU LEF1 Antibody Human,Mouse,Rat ELISA,WB,IHC
CSB-PA020264 Phospho-LEF1 (S42) Antibody Human,Mouse,Rat WB,ELISA
CSB-PA088510 LEF1 Antibody Human,Mouse,Rat ELISA,IHC
CSB-PA069370 LEF1 Antibody Human,Mouse,Rat ELISA,IHC

LEF1 Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA012856LA01HU LEF1 Antibody Human ELISA, IHC, IF
CSB-PA012856LB01HU LEF1 Antibody, HRP conjugated Human ELISA
CSB-PA012856LC01HU LEF1 Antibody, FITC conjugated Human ELISA
CSB-PA012856LD01HU LEF1 Antibody, Biotin conjugated Human ELISA

LEF1 cDNA

LEF1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL012856MO Lef1 pUC NM_010703.3

LEF1 ELISA Kit

LEF1 ELISA Kit for Mus musculus (Mouse)

Code Product Name Sample Types Sensitivity
CSB-EL012856MO Mouse Lymphoid enhancer-binding factor 1(LEF1) ELISA kit serum, plasma, tissue homogenates, cell lysates 11.72 pg/mL

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