LEF1

Lymphoid enhancer-binding factor 1 is a protein in humans that is encoded by LEF1 gene. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

LEF1 Antibodies

LEF1 Antibodies for Homo sapiens (Human)

LEF1 Antibodies for Human

LEF1 Proteins

LEF1 Proteins for Mus musculus (Mouse)

LEF1 Proteins for Rattus norvegicus (Rat)

LEF1 Proteins for Homo sapiens (Human)

LEF1 ELISA Kit

LEF1 ELISA Kit for Mus musculus (Mouse)

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