Code | CSB-RA561630A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
Through in vitro expression systems, the LEF1 recombinant monoclonal antibody is synthesized by cloning the DNA sequences of LEF1 antibodies sourced from immunoreactive rabbits. A synthesized peptide derived from the human LEF1 protein serves as the immunogen in this process. The genes encoding the LEF1 antibodies are subsequently inserted into plasmid vectors, and these recombinant plasmid vectors are transfected into host cells for antibody expression. After expression, the LEF1 recombinant monoclonal antibody is subjected to affinity-chromatography purification and is extensively tested for functionality in ELISA and IHC applications, demonstrating reactivity with the human LEF1 protein during these assessments.
LEF1 is a transcription factor with diverse functions in various biological processes, including embryonic development, tissue homeostasis, cell differentiation, and cancer. Its role as a key mediator of the Wnt signaling pathway makes it a critical regulator of gene expression and cellular responses to Wnt ligands, ultimately influencing tissue development and maintenance.
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