MARK1 Antibody

Datasheet

Code	CSB-PA873719DSR1HU
Size	US$166
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Image	Western blot All lanes: MARK1 antibody IgG at 2.65μg/ml + Rat heart tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 90, 73, 85 kDa Observed band size: 90 kDa Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA873719DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA873719DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MARK1 Polyclonal antibody

Uniprot No.

Q9P0L2

Target Names

MARK1

Alternative Names

KIAA1477 antibody; MAP/microtubule affinity regulating kinase 1 antibody; MAP/microtubule affinity-regulating kinase 1 antibody; MARK 1 antibody; MARK antibody; Mark1 antibody; MARK1_HUMAN antibody; MGC126512 antibody; MGC126513 antibody; Serine/threonine protein kinase MARK1 antibody; Serine/threonine-protein kinase MARK1 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Serine/threonine-protein kinase MARK1 protein (560-700AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Gene References into Functions

Low MARK1 is associated with cervical cancer. PMID: 29076440
Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase have been described. PMID: 27879374
the positioning of MARK/Par-1 at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions. [review] PMID: 24243102
LKB1 acts through its substrates of the microtubule affinity-regulating kinase family to regulate the localization of the polarity determinant Scribble and the activity of the core Hippo kinases PMID: 24362629
In the Australian GWAS, the SNP rs7530302 near MARK1 on chromosome 1 (p=1.90 x 10(-9) achieved genomewide significance for comorbid AD/ND. PMID: 20158304
analysis of variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2 PMID: 16803889
MARK1 was overexpressed in a prefrontal region in the brains of patients with Autism spectrum disorders. PMID: 18492799
Data show that protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. PMID: 19090997

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Involvement in disease

Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.

Subcellular Location

Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily

Tissue Specificity

Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.

Database Links

HGNC: 6896

OMIM: 606511

KEGG: hsa:4139

STRING: 9606.ENSP00000355884

UniGene: Hs.497806

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Protein Phosphorylation: The Dynamic Language of Cellular Regulation Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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