MEF2C Antibody

Datasheet
Code CSB-PA013673GA01HU
Product Type Purified Rabbit Anti Human,Mouse PolyClonal Antibody
Size US$685
Uniprot No. Q06413
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human MEF2C
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias myocyte enhancer factor 2C;
Immunogen Species Homo sapiens (Human)
Target Names MEF2C
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
HGNC 6996
RGD 1563119
MGI 99458
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Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Involvement in disease Mental retardation, autosomal dominant 20 (MRD20)
Subcellular Location Nucleus, Cytoplasm, sarcoplasm
Protein Families MEF2 family
Tissue Specificity Expressed in brain and skeletal muscle.
Database Links

HGNC: 6996

OMIM: 600662

KEGG: hsa:4208

UniGene: Hs.649965

Pathway MAPK signaling pathway
Apelin signaling pathway
cGMP-PKG signaling pathway

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