MTCH1 Antibody

Code CSB-PA868369ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: MTCH1antibody at 2.32μg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 42, 40, 20 kDa
    Observed band size: 42 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA868369ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA868369ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MTCH1 Polyclonal antibody
Uniprot No.
Target Names
MTCH1
Alternative Names
MTCH1; PSAP; CGI-64; UNQ1871/PRO4314; Mitochondrial carrier homolog 1; Presenilin-associated protein
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Mitochondrial carrier homolog 1 protein (100-250AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Potential mitochondrial transporter. May play a role in apoptosis.
Gene References into Functions
  1. Data suggest that the transmembrane domain of Bcl-XL could be involved in protein oligomerization, shown here with presenilin-1 associated protein. PMID: 21856303
  2. Results indicate that EGR-1 is a transcriptional regulator of MTCH1 and give some clues about the cellular processes in which MTCH1 might participate. PMID: 26692143
  3. Mtch1 antibody positive neuro-Bechet's disease patients had more attacks, increased disability and lower serum nucleosome levels. PMID: 24035008
  4. Data indicate that the formation of cytochrome c-Apaf-1 apoptosome and the presence of Smac are absolutely required for PSAP-induced apoptosis. PMID: 23207240
  5. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
  6. mitochondrial localization and proapoptotic activity of PSAP suggest that it is an important regulator of apoptosis PMID: 12377771
  7. PSAP has two proapoptotic isoforms generated by alternative splicing, and both proteins are imported into the mitochondrial outer membrane using multiple internal targeting signals, and both contain two proapoptotic domains. PMID: 17670888
  8. Data show that all PSAP splicing isoforms are localized in the mitochondria and are pro-apoptotic. PMID: 18291114

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Subcellular Location
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein Families
Mitochondrial carrier (TC 2.A.29) family
Tissue Specificity
Widely expressed with a predominant expression in brain.
Database Links

HGNC: 17586

OMIM: 610449

KEGG: hsa:23787

STRING: 9606.ENSP00000362718

UniGene: Hs.485262

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