NCOA1 Antibody, HRP conjugated

1. Our findings directly associate the AR/NCOA1 complex with PRKD1 regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer. PMID: 27255895
2. SRC-1 can impact osteoblast function in an estrogen receptor-independent manner. PMID: 28286232
3. The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. PMID: 26920453
4. miR-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 downstream of MEK-C/EBP-mediated leptin and insulin signaling, and that insulin and/or leptin resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC. PMID: 27842582
5. Results provide the first evidence that NCOA1 is a direct target of miR-105-1 suggesting that NCOA1 and miR-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC patients. PMID: 28060733
6. Our study indicated that genotype and allele frequencies of rs79480871 showed strong associations with MM patients (pa = 3.5x10-4 and pa = 1.5x10-4), and the rs6457327 genotype was more readily associated with MM patients than with controls PMID: 28264017
7. The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction. PMID: 28396297
8. IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner PMID: 27239967
9. Report novel PAX3-NCOA1 gene fusions in biphenotypic sinonasal sarcomas with focal rhabdomyoblastic differentiation. PMID: 26371783
10. Data indicate that finerenone inhibits mineralocorticoid receptor (MR), steroid receptor coactivator-1 binding at the regulatory sequence. PMID: 26203193
11. SRC-1 polymorphisms may be the underlying cause of coronary artery aneurysms in children with Kawasaki disease. PMID: 24652666
12. Data show that disrupting the steroid receptor coactivator-1 (SRC1) binding site on retinoid X receptor alpha (RXRalpha) alters the transactivation by CAR:RXR. PMID: 25053412
13. NCOA1 plays a necessary role in E2-induced CXCL12 expression and NCOA2 is required for P4 to inhibit the E2-induced CXCL12 production in normal and ectopic endometrium. PMID: 24586072
14. SRC1 and Twist1 expression are associated with poor survival in breast cancer. PMID: 24719557
15. SRC-1 responds to cellular energy stress in tumor cells to promote the expression of genes responsible for oxidative phosphorylation. PMID: 24438340
16. In a cohort of 453 human breast tumors, NCOA1 and CSF1 levels correlated positively with disease recurrence, higher tumor grade, and poor prognosis. PMID: 24769444
17. IL-6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the estrogen receptor alpha isoform and SRC-1 (NCOA1). PMID: 24189439
18. Elucidation of how SRC-1 controls transcription in breast cancers. PMID: 24648347
19. Overexpression of SRC-1 (NCOA1) and TIF-2 (NCOA2) increases estrogen-induced gene expression. PMID: 12403846
20. Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-transcription. PMID: 22328528
21. Our data demonstrate that SIP is a novel regulator in caspase-independent and AIF-mediated apoptosis. PMID: 22371500
22. We have identified a functional genetic variant of SRC-1 with decreased activity, resulting, at least in part, from the loss of a GSK3beta phosphorylation site, which was also associated with decreased bone mineral density in tamoxifen-treated women. PMID: 22174377
23. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role PMID: 22072566
24. The induced AF1 conformation facilitates its interaction with SRC-1, and subsequent AF1-mediated transcriptional activity. PMID: 21760925
25. NR box-2 and -3 are the essential binding targets for the SRC-1-induced stimulation of LXR transactivity; the competitive in vitro binding of NR box-2 and -3 to LXR was observed. PMID: 20682316
26. HOXC11 and SRC-1 cooperate to regulate expression of the calcium-binding protein S100beta in resistant breast cancer cells. PMID: 20145129
27. Studies expand knowledge of PAX3 variant translocations in rhabdomyossarcoma with identification of a novel PAX3-NCOA2 fusion. PMID: 19953635
28. Clomiphene citrate may inhibit E2-induced endometrial epithelial cell proliferation and ERE transactivation by inhibiting the recruitment of SRC-1 to ER alpha. PMID: 19934375
29. describes in detail the BRET(2) assay as it is used to examine the physical interaction between the nuclear receptor ERalpha and the transcriptional coactivator SRC-1 PMID: 19763509
30. CBP/p300 and NcoA/SRC1a may function in a common pathway to regulate STAT3 transcriptional activity. PMID: 11773079
31. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation PMID: 11818499
32. CAR antagonizes ER-mediated transcriptional activity by squelching limiting amounts of p160 coactivators, such as SRC-1 and GRIP-1. PMID: 12114525
33. mutation of the AF2 transactivation domain on Glucocorticoid Receptors disrupts the direct interaction of GR with steroid receptor coactivator 1 (SRC-1) PMID: 12118039
34. STAT6 has a protein binding motif that controls the interaction with NcoA-1 in transcriptional activation PMID: 12138096
35. Data show that steroid receptor coactivator-1 (SRC-1) enhanced ligand-independent activation of the AR by IL-6 to the same magnitude as that obtained via ligand-dependent activation, and that activation required MAPK. PMID: 12163482
36. our results indicate an important role for Mediator, as well as its functional interplay with p300/CBP-SRC, in the enhancement of ERalpha-dependent transcription with chromatin templates PMID: 12482985
37. Sumoylation was shown to increase progesterone receptor-SRC-1 interaction and to prolong SRC-1 retention in the nucleus. PMID: 12529333
38. is a coactivator of MHC class II genes that stimulates their interferon gamma (IFNgamma) and class II transactivator (CIITA)-mediated expression. PMID: 12933903
39. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain PMID: 12954634
40. differential recruitment of steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors by estrogen receptor-alpha and beta in breast cancer may be central to the response of the tumor to endocrine treatment PMID: 14715875
41. surface complementarity between the hydrophobic faces of the STAT6 fragment and of the NCoA-1 PAS-B domain almost exclusively defines the binding specificity between the two proteins PMID: 14757047
42. TNF-alpha impairs progesterone-stimulated PR-B-mediated transactivation, and these effects appear to be due, in part, to reduced expression of SRC-1 and -2 PMID: 15231721
43. A novel translocation t(2;2)(q35;p23), which generates a fusion protein composed of PAX3 and the NCOA1was identified in rhabdomyosarcoma. PMID: 15313887
44. Data show that steroid receptor coactivator-1 (SRC-1) overexpressing cells are more responsive to Po mRNA induction by dihydroprogesterone (DHP) than SRC-1-deficient cells, and that DHP treatment increases not only Po but also SRC-1 mRNA levels. PMID: 15456935
45. The conserved STAT3 region from 752 to 761, called STAT3 CR2, plays critical roles in STAT3-dependent transcription by recruiting SRC-1 and allowing Ser727 phosphorylation. PMID: 15530426
46. The SRC-1 has been shown to be involved in HIF-1alpha-mediated activation of transcription. PMID: 15615775
47. SRC-1 and SMRT content change in a tissue-specific manner in the rat brain during the estrous cycle. PMID: 15862975
48. ASXL1 is a novel coactivator of RAR that cooperates with SRC-1 PMID: 16606617
49. SRC1-deficient P19 cells showed severely compromised retinoid-induced responses, in agreement with the supposed role of SRC1 as a retinoic acid recepetor coactivator. PMID: 16723356
50. HPV E7 proteins dysregulate hormone-dependent gene expression by association with and relocalization of SRC-1. PMID: 16775354

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HGNC: 7668

OMIM: 602691

KEGG: hsa:8648

STRING: 9606.ENSP00000320940

UniGene: Hs.596314