NEUROG1 Antibody

Code CSB-PA100644
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA100644(NEUROG1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA100644(NEUROG1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
NEUROG1
Alternative Names
AKA antibody; Ath4c antibody; bHLHa6 antibody; Class A basic helix-loop-helix protein 6 antibody; Helix loop helix protein mATH 4C antibody; MATH4C antibody; NeuroD3 antibody; Neurog 1 antibody; Neurog1 antibody; Neurogenic basic helix loop helix protein antibody; Neurogenic basic-helix-loop-helix protein antibody; Neurogenic differentiation 3 antibody; Neurogenic differentiation factor 3 antibody; Neurogenin-1 antibody; Neurogenin1 antibody; Ngn antibody; NGN-1 antibody; Ngn1 antibody; NGN1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human NEUROG1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
WB 1:200-1:1000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
Gene References into Functions
  1. mutation not found in group of children with sensorineural hearing loss PMID: 26634621
  2. Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media. PMID: 25403753
  3. We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder PMID: 23419067
  4. Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer. PMID: 23034738
  5. NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer. PMID: 21326223
  6. Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks. PMID: 19813087
  7. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. PMID: 20102160
  8. Overexpression of the full-length Ngn1 induced neurite outgrowth in F11 cells in the absence of cAMP PMID: 12526089
  9. These results, along with a priori evidence for the involvement of neurog1 in neurodevelopment, suggest that variants in neurog1 might have a small effect on susceptibility to schizophrenia. PMID: 17044100
  10. Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1. PMID: 18799289

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Subcellular Location
Nucleus.
Tissue Specificity
Expression restricted to the embryonic nervous system.
Database Links

HGNC: 7764

OMIM: 601726

KEGG: hsa:4762

STRING: 9606.ENSP00000317580

UniGene: Hs.248149

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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