NFE2L2 Antibody

Datasheet
Code CSB-PA003481
Size US$167
Image
  • Western Blot analysis of HuvEc cells using Nrf2 Polyclonal Antibody
  • Western Blot analysis of KB HELA cells using Nrf2 Polyclonal Antibody

Product Details

Uniprot No. Q16236
Target Names NFE2L2
Alternative Names NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the C-terminal region of Human Nrf2.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Citations

17β-estradiol protects mesenchymal stem cells against high glucose-induced mitochondrial oxidants production via Nrf2/Sirt3/MnSOD signaling. Oh JY, et al,Free Radical Biology and Medicine,2018

Sample type: UCB-MSCs
Sample species: Human
Application: WB
Review: Cells were transfected with ERα siRNA or NT siRNA for 24 h prior to high glucose treatment for 72 h where nuclear fraction was carried out. Nuclear Nrf2 was detected by western blot. Lamin A/C was used as the nuclear marker.
PMID: 30412732

Target Data

Function Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Subcellular Location Cytoplasm, cytosol, Nucleus
Protein Families BZIP family, CNC subfamily
Tissue Specificity Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Database Links

HGNC: 7782

OMIM: 600492

KEGG: hsa:4780

STRING: 9606.ENSP00000380252

UniGene: Hs.744006

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