Code | CSB-RA614961A40phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
CUSABIO got the DNA sequence of the phospho-NFE2L2 (S40) monoclonal antibody that was produced from the splenocytes generated by the phosphopeptide corresponding to human NFE2L2 (phospho S40) immunization. The DNA sequence was cloned into the plasmid and then transfected the into cell lines for in vitro expression. The product is the phospho-NFE2L2 (S40) recombinant monoclonal antibody. It is a rabbit IgG antibody purified using the affinity-chromatography method. This phospho-NFE2L2 (S40)antibody is recommended for WB, IHC, and IF applications and detects the human NFE2L2 phosphorylated at Ser 40 residue.
NFE2L2 is a transcription factor that regulates the physiological response to ROS and oxidative stress. PKC phosphorylates NFE2L2 at Ser40 in response to oxidative stress. Phosphorylated NFE2L2 at Ser40 has been shown to assist its liberation from the cytoplasmic anchor KEAP1 and trigger nuclear translocation. The phosphorylation of NFE2L2 at Ser40 by PKC is a crucial signaling event that leads to a cellular antioxidant response mediated by the antioxidant response element (ARE).
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