Nid1 Antibody, Biotin conjugated

Code CSB-PA015802LD01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Nid1 Polyclonal antibody
Uniprot No.
Target Names
Nid1
Alternative Names
Nid1 antibody; Ent antibody; Nidogen-1 antibody; NID-1 antibody; Entactin antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Nidogen-1 protein (428-665AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Gene References into Functions
  1. Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes. PMID: 25387007
  2. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation. PMID: 23948589
  3. nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels. PMID: 24280453
  4. finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions PMID: 22623588
  5. show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane PMID: 22260998
  6. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. PMID: 21084308
  7. This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity. PMID: 19530222
  8. Results suggest a non-structural role for nidogen 1 in wound repair. PMID: 19766719
  9. Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. PMID: 12015298
  10. These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized. PMID: 12243745
  11. Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
  12. structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5) PMID: 12931195
  13. Expression may promote formation of sinusoids after partial hepatectomy. PMID: 15777791
  14. Laminin gamma3 chain, located in murine basement membranes, binds to nidogen PMID: 15824114
  15. Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue PMID: 16024816
  16. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
  17. nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud PMID: 17023412
  18. expression of the entactin-1 dramatically declined in myogenesis PMID: 17177854
  19. The lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes. PMID: 17616934
  20. In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV, perlecan, and particularly laminin-411. PMID: 18356808

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Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Database Links
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