P4hb Antibody, HRP conjugated

Datasheet

Code	CSB-PA017342YB01MO
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) P4hb Polyclonal antibody

Uniprot No.

P09103

Target Names

P4hb

Alternative Names

P4hb antibody; Pdia1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Cellular thyroid hormone-binding protein antibody; Endoplasmic reticulum resident protein 59 antibody; ER protein 59 antibody; ERp59 antibody; Prolyl 4-hydroxylase subunit beta antibody; p55 antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Protein disulfide-isomerase protein (20-509AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Gene References into Functions

Unfolded protein response caused by protein misfolding, may lead to PDI-dependent NOX activation and contribute to neurotoxicity in neurodegenerative diseases including ALS. PMID: 23118353
PDI from endothelial cells is required for fibrin generation in vivo. PMID: 20668226
Protein disulfide isomerase (PDI) on the platelet surface is recognized by anti-dengue virus NS1 antibodies. PMID: 19822367

Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein.

Protein Families

Protein disulfide isomerase family

Database Links

KEGG: mmu:18453

STRING: 10090.ENSMUSP00000026122

UniGene: Mm.16660

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The Overview of Organelles Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum ER Stress pathway

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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