PDIA6 Antibody

Code CSB-PA622988DSR1HU
Size US$166
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  • Western blot
    All lanes: PDIA6 antibody at 5.9µg/ml
    Lane 1: Mouse heart tissue
    Lane 2: Mouse lung tissue
    Lane 3: Mouse liver tissue
    Lane 4: 293T whole cell lysate
    Lane 5: Hela whole cell lysate
    Lane 6: HL60 whole cell lysate
    Lane 7: HepG2 whole cell lysate
    Lane 8: THP-1 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 49, 54, 48 kDa
    Observed band size: 54 kDa

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA622988DSR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDIA6 Polyclonal antibody
Uniprot No.
Target Names
PDIA6
Alternative Names
Endoplasmic reticulum protein 5 antibody; ER protein 5 antibody; ERp5 antibody; P5 antibody; Pdia6 antibody; PDIA6_HUMAN antibody; Protein disulfide isomerase A6 antibody; Protein disulfide isomerase associated 6 antibody; Protein disulfide isomerase family A member 6 antibody; Protein disulfide isomerase P5 antibody; Protein disulfide isomerase related protein antibody; Protein disulfide-isomerase A6 antibody; Thioredoxin domain containing 7 (protein disulfide isomerase) antibody; Thioredoxin domain containing protein 7 antibody; Thioredoxin domain-containing protein 7 antibody; TXNDC7 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Protein disulfide-isomerase A6 protein (20-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Gene References into Functions
  1. Results indicate that protein disulfide isomerase family 6 (PDIA6) overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway. PMID: 27462866
  2. the chaperone 78-kDa glucose-regulated protein (GRP78) protects the MPD against PDI-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition. PMID: 28949004
  3. Downregulation of PDIA6 inhibited BC cell proliferation and invasion in vitro as well as tumor growth and metastasis in vivo. In addition, PDIA6 downregulation suppressed the Wnt/beta-catenin signaling pathway. PMID: 27760590
  4. Results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. PMID: 28866093
  5. ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head. PMID: 26676989
  6. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. PMID: 26655997
  7. PDIA3 and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer. PMID: 26125904
  8. CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 and PDIA6. PMID: 24464223
  9. Txnip is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip increases PDI activity. PMID: 24843047
  10. levels of expression of ERp5 and GRP78 correlated with the level of expression of membrane-bound MICA in chronic lymphocytic leukemia patients. PMID: 22215138
  11. Data show that the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell membrane. PMID: 22167753
  12. P5 forms a non-covalent complex with immunoglobulin heavy chain binding protein (BiP) and shows specificity towards BiP client proteins. PMID: 19887585
  13. observed to have peptide-binding ability, and chaperone activity was confirmed with rhodanese and citrate synthase as substrates, but not with D-glyceraldehyde-3-phosphate dehydrogenase, showing substrate specificity with respect to chaperone activity PMID: 12204115
  14. ERP5 regulates the binding of fibrinogen, cell-surface exposure of P-selectin, and coassociation of beta 3 integrin in stimulated platelets. PMID: 15466936
  15. Pharmacological inhibition of thioreductase activity and ERp5 gene silencing revealed that cell-surface ERp5 function is required for MICA shedding PMID: 17495932

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Subcellular Location
Endoplasmic reticulum lumen. Cell membrane. Melanosome.
Protein Families
Protein disulfide isomerase family
Tissue Specificity
Expressed in platelets (at protein level).
Database Links

HGNC: 30168

OMIM: 611099

KEGG: hsa:10130

STRING: 9606.ENSP00000272227

UniGene: Hs.212102

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