PFKM Antibody

1. KLK6 may be the key protease involved in the proteolytic modification of PFK-M. PMID: 29563071
2. characterize three PFK1 mutations and show they have distinct effects on allosteric regulation of PFKP activity and lactate production. PMID: 25985179
3. Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6). PMID: 24493630
4. insulin/phosphofructokinase (PFKM), overlaps with an expression quantitative trait loci PMID: 24306210
5. Asp(543)Ala, a naturally occurring Tarui disease-causing mutation in the activating binding site, causes an increased efficacy of ATP at the inhibitory allosteric binding site. PMID: 22995305
6. Molecular genetic findings demonstrated the absence of specific genotype-phenotype correlations in PFKM gene mutations. PMID: 22133655
7. eukaryotic Pfk did not evolve from prokaryotic ancestors, reciprocal linkage of functionally opposed allosteric binding sites must have developed independently in prokaryotic and eukaryotic Pfk (convergent evolution). PMID: 22474333
8. Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors PMID: 21573193
9. Data indicate that substitution of residue at the citrate-binding site (D591V) of PFK-M resulted in the complete loss of activity. PMID: 21124851
10. Glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFK-L over the M and P isoforms. PMID: 20483646
11. Identification of novel PFK-M transcripts in the testis and embryo. PMID: 15020257
12. Two phosphofructokinase (PFK) chimeras were constructed by exchanging the N- and C-terminal halves of the mammalian M- and C-type isozymes. PMID: 17544406

Show More

Hide All

HGNC: 8877

OMIM: 232800

KEGG: hsa:5213

STRING: 9606.ENSP00000345771

UniGene: Hs.75160