PGRMC2 Antibody

Datasheet

Code	CSB-PA986206
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA986206(PGRMC2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: X200) Gel: 12%SDS-PAGE, Lysate: 40μg, Lane: NIH/3T3 cell, Primary antibody: CSB-PA986206(PGRMC2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

O15173

Target Names

PGRMC2

Alternative Names

PGRMC2; DG6; PMBP; Membrane-associated progesterone receptor component 2; Progesterone membrane-binding protein; Steroid receptor protein DG6

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human PGRMC2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:20-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.

Gene References into Functions

Demonstrate a change in myometriumPGRMC1 expression and changes in PGRMC1 and PGRMC2 cell localisation in association with parturition. PMID: 25266650
It deserves further examination as data point to a role of PGRMC2 as tumor suppressor, migration inhibitor and regulator of cytochrome P450 proteins. PMID: 23276631
In secretory phase endometrium from women with advanced stage endometriosis, PGRMC-2 expression is downregulated. PMID: 23793472
Reversely, in the HO-8910 cells treated with CDDP alone, levels of both PGRMC1 and PGR were increased while the level of PGRMC2 was decreased PMID: 23970345
PGRMC2 inhibits migration of SKOV-3 ovarian cancer cells in vitro. PMID: 23064006
The expression of a novel progesterone-binding protein (hmPR1/PGMRC1) was investigated. Transcripts of this protein have been detected in human sperm. PMID: 15702432

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Subcellular Location

Membrane; Single-pass membrane protein. Nucleus envelope. Endoplasmic reticulum.

Protein Families

Cytochrome b5 family, MAPR subfamily

Tissue Specificity

Expressed by endometrial glands and stroma (at protein level).

Database Links

HGNC: 16089

OMIM: 607735

KEGG: hsa:10424

STRING: 9606.ENSP00000429301

UniGene: Hs.507910

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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