PLAA Antibody

Datasheet

Code	CSB-PA018107GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9Y263

Target Names

PLAA

Alternative Names

FLJ11281 antibody; FLJ12699 antibody; Glycerophosphatase antibody; OTTHUMP00000045176 antibody; Phospholipase A 2 activating protein antibody; Phospholipase A-2-activating protein antibody; Phospholipase A2 activating protein antibody; PLA2P antibody; Plaa antibody; PLAP antibody; PLAP_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PLAA

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.

Gene References into Functions

In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures. PMID: 28413018
This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. PMID: 28007986
This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 via PLAA and CaMKII, a process initiated by Pdia3/PLAA interaction, which further triggers CaMKII-dependent PLA2 activation. [review] PMID: 25448737
Function assignment to conserved residues in mammalian alkaline phosphatases. PMID: 11937510
PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes PMID: 14499668
identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene PMID: 18291623
Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein PMID: 19423704

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Involvement in disease

Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)

Subcellular Location

Nucleus. Cytoplasm. Cell junction, synapse.

Protein Families

WD repeat PLAP family

Database Links

HGNC: 9043

OMIM: 603873

KEGG: hsa:9373

STRING: 9606.ENSP00000380460

UniGene: Hs.27182

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Related pathways

Protein processing in endoplasmic reticulum

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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