PNOC Antibody

1. found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype. PMID: 27983768
2. The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants. PMID: 26791055
3. Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW] PMID: 25677772
4. Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW] PMID: 25677774
5. REVIEW: intracellular localization and physiological role of nociceptin and nocistatin PMID: 23454174
6. Strong expression of PNOC was seen in neoplastic neurons of 7/7 brainstem gangliogliomas, but was significantly weaker in non-brainstem GGs. PMID: 22706982
7. The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord.[Orphanin] PMID: 21744319
8. A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue. PMID: 21600132
9. chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma nociceptin levels PMID: 21310194
10. PNOC expression level was 2.99 times higher in vitiligo involved skin when compared to healthy control skin. PMID: 20888736
11. Results showed that vigorous and prolonged hyperventilation changes plasma nociceptin/orphanin FQ levels due to the direct effects of hypocapnic alkalosis or to different sympatho-adrenergic system responses. PMID: 20100531
12. Peripheral blood levels are elevated in Wilson disease PMID: 12812047
13. results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues PMID: 12950177
14. The presence of two different forms of mature nocistatin (NST-17 and NST-30) and a possible N-terminal methionine cleaved NST-29 have been confirmed by both radioimmunoassay and mass spectrometry. PMID: 16043263
15. Two SNPs in PNOC showed marginal association with alcoholism and one with illicit drug dependence. PMID: 17910740
16. Peripheral blood mononuclear cells transcribe pre-pro-nociception/orphaninFQ. PMID: 18292431
17. Unstable angina is associated with a significant increase in circulating nociceptin/orphanin FQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. PMID: 19560501

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HGNC: 9163

OMIM: 601459

KEGG: hsa:5368

STRING: 9606.ENSP00000301908

UniGene: Hs.88218