POLA2 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA614517LD01HU
Size	US$166
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLA2 Polyclonal antibody

Uniprot No.

Q14181

Target Names

POLA2

Alternative Names

AI573378 antibody; DNA directed DNA polymerase alpha 2 antibody; DNA polymerase alpha 70 kDa subunit antibody; DNA polymerase alpha subunit B antibody; DNA polymerase alpha subunit II antibody; DNA polymerase subunit alpha B antibody; DNA polymerase subunit II antibody; DPOA2_HUMAN antibody; FLJ21662 antibody; FLJ37250 antibody; polA2 antibody; Polymerase (DNA directed) alpha 2 (70kD subunit) antibody; Polymerase (DNA directed); alpha (70kD) antibody; Polymerase (DNA directed); alpha 2 accessory subunit antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA polymerase alpha subunit B protein (101-400AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively.

Gene References into Functions

STN1-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1. PMID: 28934486
our findings showed that knockdown of POLA2 increases gemcitabine resistance in human lung cancer cells. We propose that POLA2 may play a role in gemcitabine sensitivity and can be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis. PMID: 28155658
POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis PMID: 25521664
Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. PMID: 22593576

Subcellular Location

Nucleus.

Protein Families

DNA polymerase alpha subunit B family

Database Links

HGNC: 30073

KEGG: hsa:23649

STRING: 9606.ENSP00000265465

UniGene: Hs.201897

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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