POLA2 is a protein in humans that is encoded by POLA2 gene. Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).
The following POLA2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
POLA2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA018301GA01HU | POLA2 Antibody |
Human | ELISA,WB |
CSB-PA614517LA01HU | POLA2 Antibody |
Human | ELISA |
CSB-PA614517LB01HU | POLA2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA614517LC01HU | POLA2 Antibody, FITC conjugated |
Human | |
CSB-PA614517LD01HU | POLA2 Antibody, Biotin conjugated |
Human | ELISA |
POLA2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP018301MO CSB-EP018301MO CSB-BP018301MO CSB-MP018301MO CSB-EP018301MO-B |
Recombinant Mouse DNA polymerase alpha subunit B (Pola2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP018301RA CSB-EP018301RA CSB-BP018301RA CSB-MP018301RA CSB-EP018301RA-B |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP614517HU CSB-EP614517HU CSB-BP614517HU CSB-MP614517HU CSB-EP614517HU-B |
Recombinant Human DNA polymerase alpha subunit B (POLA2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA2 Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP690693DKK CSB-EP690693DKK CSB-BP690693DKK CSB-MP690693DKK CSB-EP690693DKK-B |
Recombinant Dictyostelium discoideum DNA polymerase alpha subunit B (polA2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLA2 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP701509BO CSB-EP701509BO CSB-BP701509BO CSB-MP701509BO CSB-EP701509BO-B |
Recombinant Bovine DNA polymerase alpha subunit B (POLA2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |