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| Code | CSB-PA592613 |
| Product Type | Polyclonal Antibody |
| Size | US$297 |
| Uniprot No. | Q13131 |
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| Immunogen | Peptide sequence around aa.485~489 (S-G-S-V-S) derived from Human AMPKa1. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Specificity | The antibody detects endogenous level of total AMPKa1 protein. |
| Tested Applications | ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200 |
| Relevance | Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Kim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346. Woods A, et al. (2003) J Biol Chem. 278(31): 28434-28442. |
| Form | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Clonality | Polyclonal |
| Alias | AAPK1; AMPK alpha-1 chain; AMPK-alpha1; HMG-CoA redustase kinase; PRKAA1 |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Target Names | PRKAA1/PRKAA2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes |
| Subcellular Location | Cytoplasm, Nucleus |
| Protein Families | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily |
| Database Links |
HGNC: 9376 OMIM: 602739 KEGG: hsa:5562 STRING: 9606.ENSP00000346148 UniGene: Hs.43322 |
| Pathway |
mTOR signaling pathway
PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling Apelin signaling pathway FoxO signaling pathway Glucagon signaling pathway Insulin signaling pathway |
PRKAA1/PRKAA2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA618759KA01HU | PRKAA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IP |
| CSB-PA261465 | Phospho-PRKAA1/PRKAA2 (Ser487) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA913725 | PRKAA1 (Ab-174/172) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA131259 | PRKAA1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA953053 | Phospho-PRKAA1 (S496) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA865713 | PRKAA1 Antibody | Human,Mouse,Rat | WB |
| CSB-PA801858 | PRKAA1 Antibody | Human,Mouse,Rat | WB,IHC |
| CSB-PA228254 | PRKAA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA345903 | PRKAA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA071831 | PRKAA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
PRKAA1/PRKAA2 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA618759LA01HU | PRKAA1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA618759LB01HU | PRKAA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA618759LC01HU | PRKAA1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA618759LD01HU | PRKAA1 Antibody, Biotin conjugated | Human | ELISA |
PRKAA1/PRKAA2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP618759HU CSB-EP618759HU CSB-BP618759HU CSB-MP618759HU |
Recombinant Human 5'-AMP-activated protein kinase catalytic subunit alpha-1(PRKAA1) | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H2BC (K34) Antibody
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Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K23) Antibody
Applications: ELISA, WB, IF, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K16) Antibody
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