PRKAA1/PRKAA2 (Ab-487) Antibody

^Datasheet

Specification
Target

Code	CSB-PA592613
Product Type	Polyclonal Antibody
Size	US$297
Uniprot No.	Q13131
Image	Western blot analysis of extracts from 293 cells using AMPKa1(Ab-487)Antibody. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using AMPKa1(Ab-487)Antibody(left) or the same antibody preincubated with blocking peptide(right).
Immunogen	Peptide sequence around aa.485~489 (S-G-S-V-S) derived from Human AMPKa1.
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Specificity	The antibody detects endogenous level of total AMPKa1 protein.
Tested Applications	ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200
Relevance	Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. Kim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346. Woods A, et al. (2003) J Biol Chem. 278(31): 28434-28442.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality	Polyclonal
Alias	AAPK1; AMPK alpha-1 chain; AMPK-alpha1; HMG-CoA redustase kinase; PRKAA1
Immunogen Species	Homo sapiens (Human)
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol
Target Names	PRKAA1/PRKAA2
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions?	Leave a Message or Start an on-line Chat

Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes
Subcellular Location	Cytoplasm, Nucleus
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Database Links	HGNC: 9376 OMIM: 602739 KEGG: hsa:5562 STRING: 9606.ENSP00000346148 UniGene: Hs.43322
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling Apelin signaling pathway FoxO signaling pathway Glucagon signaling pathway Insulin signaling pathway

Related Products

PRKAA1/PRKAA2 Antibody

PRKAA1/PRKAA2 Protein

PRKAA1/PRKAA2 Antibodies

PRKAA1/PRKAA2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA618759KA01HU	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IP
CSB-PA261465	Phospho-PRKAA1/PRKAA2 (Ser487) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA913725	PRKAA1 (Ab-174/172) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA131259	PRKAA1 Antibody	Human,Mouse,Rat	WB,IHC,IF,ELISA
CSB-PA953053	Phospho-PRKAA1 (S496) Antibody	Human,Mouse,Rat	WB,IHC,ELISA
CSB-PA865713	PRKAA1 Antibody	Human,Mouse,Rat	WB
CSB-PA801858	PRKAA1 Antibody	Human,Mouse,Rat	WB,IHC
CSB-PA228254	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA345903	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA071831	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

PRKAA1/PRKAA2 Antibodies for Human

Code	Product Name	Species Reactivity	Application
CSB-PA618759LA01HU	PRKAA1 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA618759LB01HU	PRKAA1 Antibody, HRP conjugated	Human	ELISA
CSB-PA618759LC01HU	PRKAA1 Antibody, FITC conjugated	Human	ELISA
CSB-PA618759LD01HU	PRKAA1 Antibody, Biotin conjugated	Human	ELISA

PRKAA1/PRKAA2 Proteins

PRKAA1/PRKAA2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP618759HU CSB-EP618759HU CSB-BP618759HU CSB-MP618759HU	Recombinant Human 5'-AMP-activated protein kinase catalytic subunit alpha-1(PRKAA1)	Yeast E.coli Baculovirus Mammalian cell

CloseMessage

Product >> Product Name：
Product >> Code：
Product >> Size：
Name： *
Email： *
Phone：
We recommend you to leave your phone number because occasionally our emails get flagged by spam filters. We would not disclose any of your private information to any third party.
Question/Comment： *
Your Region： *
Country State：
I'd like to receive email newsletters from Cusabio

Yes

No
How did you know this promotion?

Email

Distributor

Search engine

Advertisement

Others
Check Code：

PRKAA1/PRKAA2 (Ab-487) Antibody

Related Products

PRKAA1/PRKAA2 Antibodies

PRKAA1/PRKAA2 Proteins

Most popular with customers

CloseMessage