PSEN1 Antibody

Datasheet
Code CSB-PA695720
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P49768
Image
  • Western blot analysis of extracts from mouse heart cells, using presenilin 1 antibody.
  • Immunohistochemical analysis of paraffin-embedded human brain tissue using presenilin 1 antibody.
Immunogen Synthesized peptide derived from Human presenilin 1.
Raised in Rabbit
Species Reactivity Human
Specificity The antibody detects endogenous levels of total presenilin 1 protein.
Tested Applications ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
Relevance Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376.
I. Imafuku, J. Cell Biol., Oct 1999; 147: 121.
Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105.
Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias AD3; AD3H; PS-1; PS1; PSN1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names PSEN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)
Involvement in disease Alzheimer disease 3 (AD3); Frontotemporal dementia (FTD); Cardiomyopathy, dilated 1U (CMD1U); Acne inversa, familial, 3 (ACNINV3)
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Cytoplasmic granule, Cell membrane
Protein Families Peptidase A22A family
Tissue Specificity Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level) (PubMed:11987239). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes (PubMed:7596406, PubMed:86
Database Links

HGNC: 9508

OMIM: 104311

KEGG: hsa:5663

STRING: 9606.ENSP00000326366

UniGene: Hs.3260

Pathway Notch signaling pathway
Wnt signaling pathway
Neurotrophin signaling pathway

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