PSEN1

PSEN1, or presenilin-1, is a product of a gene located on chromosome 14 and is an integral part of the γ-secretase complex. It is instrumental in the processing of membrane proteins like APP and Notch, which in turn impacts neuronal survival and synaptic plasticity. PSEN1 abnormalities are often seen in Alzheimer's disease and can exacerbate neurotoxicity and amyloid plaque formation by disrupting Aβ peptide balance. As such, PSEN1 is a focal point in Alzheimer's research, and a deeper understanding of its mechanisms could pave the way for new treatment strategies to combat or delay the disease's progression.

Popular Product:

PSEN1 Antibody (CSB-PA018846ESR2HU)

Validated Data

Western blot
All lanes: PSEN1 antibody at 2µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 43, 22, 47, 49 kDa
Observed band size: 53 kDa

Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA018846ESR2HU at dilution of 1:100

The following PSEN1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PSEN1 Antibodies

PSEN1 Proteins

PSEN1 Antibodies

PSEN1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA018846GA01HU	PSEN1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA018846ESR2HU	PSEN1 Antibody	Human	ELISA, WB, IHC
CSB-PA695720	PSEN1 Antibody	Human	ELISA,WB,IHC
CSB-PA040014	Phospho-PSEN1 (S357) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA040015	PSEN1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA040016	PSEN1 Antibody	Human	WB, IHC, ELISA
CSB-PA018846EA01HU	PSEN1 Antibody	Human	ELISA, WB, IHC
CSB-PA018846EB01HU	PSEN1 Antibody, HRP conjugated	Human	ELISA
CSB-PA018846EC01HU	PSEN1 Antibody, FITC conjugated	Human
CSB-PA018846ED01HU	PSEN1 Antibody, Biotin conjugated	Human	ELISA

PSEN1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA895711XA01DIL	psen1 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

PSEN1 Proteins

PSEN1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP678302CH CSB-EP678302CH CSB-BP678302CH CSB-MP678302CH CSB-EP678302CH-B	Recombinant Chicken Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP735706PYX CSB-EP735706PYX CSB-BP735706PYX CSB-MP735706PYX CSB-EP735706PYX-B	Recombinant Pongo abelii Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP747558DO CSB-EP747558DO CSB-BP747558DO CSB-MP747558DO CSB-EP747558DO-B	Recombinant Dog Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP818178MOV CSB-EP818178MOV CSB-BP818178MOV CSB-MP818178MOV CSB-EP818178MOV-B	Recombinant Macaca fascicularis Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP895480BO CSB-EP895480BO CSB-BP895480BO CSB-MP895480BO CSB-EP895480BO-B	Recombinant Bovine Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP895711DIL CSB-EP895711DIL CSB-BP895711DIL CSB-MP895711DIL CSB-EP895711DIL-B	Recombinant Danio rerio Presenilin-1 (psen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP018846RA CSB-EP018846RA CSB-BP018846RA CSB-MP018846RA CSB-EP018846RA-B	Recombinant Rat Presenilin-1 (Psen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP018846MO CSB-EP018846MO CSB-BP018846MO CSB-MP018846MO CSB-EP018846MO-B	Recombinant Mouse Presenilin-1 (Psen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP018846HU CSB-EP018846HU CSB-BP018846HU CSB-MP018846HU CSB-EP018846HU-B	Recombinant Human Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur)

Code	Product Name	Source
CSB-YP018846MFU CSB-EP018846MFU CSB-BP018846MFU CSB-MP018846MFU CSB-EP018846MFU-B	Recombinant Microcebus murinus Presenilin-1 (PSEN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PSEN1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP018846XBE CSB-EP018846XBE CSB-BP018846XBE CSB-MP018846XBE CSB-EP018846XBE-B	Recombinant Xenopus laevis Presenilin-1 (psen1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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