PSEN1 Antibody

Datasheet
Code CSB-PA018846ESR2HU
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Uniprot No. P49768
Image
  • Western blot
    All lanes: PSEN1 antibody at 2µg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 53, 43, 22, 47, 49 kDa
    Observed band size: 53 kDa

  • Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA018846ESR2HU at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Presenilin-1 protein (1-160AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Relevance Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)], PSEN1, AD3 PS1 PSNL1
Immunogen Species Human
Research Area Neuroscience
Target Names PSEN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)
Involvement in disease Alzheimer disease 3 (AD3); Frontotemporal dementia (FTD); Cardiomyopathy, dilated 1U (CMD1U); Acne inversa, familial, 3 (ACNINV3)
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Cytoplasmic granule, Cell membrane
Protein Families Peptidase A22A family
Tissue Specificity Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level) (PubMed:11987239). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes (PubMed:7596406, PubMed:86
Database Links

HGNC: 9508

OMIM: 104311

KEGG: hsa:5663

STRING: 9606.ENSP00000326366

UniGene: Hs.3260

Pathway Notch signaling pathway
Wnt signaling pathway
Neurotrophin signaling pathway

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