PSENEN Antibody, HRP conjugated

Datasheet
Code CSB-PA878932OB01HU
Size US$299
Uniprot No. Q9NZ42
Protocols ELISA Protocol
Immunogen Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2), PSENEN, PEN2
Immunogen Species Homo sapiens (Human)
Research Area Neuroscience
Target Names PSENEN
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)
Involvement in disease Acne inversa, familial, 2 (ACNINV2)
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus, Golgi stack membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Membrane, Multi-pass membrane protein
Protein Families PEN-2 family
Tissue Specificity Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Database Links

HGNC: 30100

OMIM: 607632

KEGG: hsa:55851

STRING: 9606.ENSP00000222266

UniGene: Hs.534465

Pathway Notch signaling pathway

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