Phospho-SNAI1 (Ser246) Antibody

1. Snail1 gene silencing effectively improved the drug sensitivity of MMCs to bortezomib chemotherapy. PMID: 30365089
2. Up-regulation of long non-coding RNA XLOC_010235 regulates epithelial-to-mesenchymal transition to promote metastasis by associating with Snail1 in gastric cancer. PMID: 28550287
3. Study provides evidence that genetic variants in SNAI1 and TWIST1 are associated with breast cancer (BC) and ovarian cancer (OC) susceptibility and suggests a synergistic effect of those related loci on BC/OC risk. PMID: 30272327
4. Ovarian cancer patients show elevated serum CXCL1/2, which correlates with Snail expression, myeloid-derived suppressor cells infiltration, and short overall survival. Snail induces ovarian cancer progression via upregulation of CXCR2 ligands and recruitment of myeloid-derived suppressor cells. PMID: 29703902
5. The authors identify SNAI1 as the key Epithelial-Mesenchymal Transition transcriptional factor required for the specification of definitive endoderm. PMID: 28466868
6. Snail functions as a metabolic switch between aerobic glycolysis and pentose phosphate pathway by repressing PFKP, a cancer-specific PFK-1, allowing cancer cell survival under metabolic stress. PMID: 28176759
7. At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated on nicotinic acid addition, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to nicotinic acid's ability to facilitate the ubiquitination and degradation of Snail1, a transcription factor that represses E-cadherin expression. PMID: 28256591
8. Dub3 is identified as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. PMID: 28198361
9. High SNAIL1 expression is associated with breast invasive ductal carcinoma. PMID: 29937187
10. The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196
11. Binding of HIV1 Tat to TIP30 enhanced epithelial-to-mesenchymal transition and metastasis by regulating the nuclear translocation of Snail. PMID: 30099830
12. Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating the expression of ephrin-B1. PMID: 30058095
13. FBXW7 conduction of tumour suppression was partly through degrading Snai1 directly for ubiquitylating regulation in NSCLC. PMID: 30094882
14. It is concluded that epithelial-mesenchymal transition is involved in human diabetic cataract, and upregulation of miR-30a can repress epithelial-mesenchymal transition through its targeting of SNAI1 in lens epithelial cells, which make miR-30a a novel target of therapeutic intervention for human diabetic cataract. PMID: 28442786
15. irradiation of Human Umbilical Vein Endothelial Cells induced the differentiation of fibroblasts into myofibroblasts through the Snail/miR-199a-5p axis. PMID: 29619372
16. these results indicate that miR124 transection inhibits the growth and aggressive of osteosarcoma, potentially via suppression of TGFbetamediated AKT/GSK3beta/snail family transcriptional repressor 1 (SNAIL1) signaling, suggesting miR124 may be a potential anticancer agent/target for osteosarcoma therapy. PMID: 29488603
17. MiR-30c inhibits ESCC biological behaviors and EMT progress by directly binding to the 3'-UTR of SNAI1. PMID: 29304493
18. MiR-22 over-expression attenuated lung cancer cell EMT and invasion via targeted inhibiting Snail. PMID: 28925484
19. High glucose enhances the formation of EZH2/Snail/HDAC1 complex in the nucleus, which in turn causes E-cadherin repression. PMID: 29705809
20. Neutrophils and Snail orchestrate the establishment of a pro-tumor microenvironment in lung cancer. PMID: 29241546
21. Snail-1 plays a major role in the progression and migration of urinary bladder cancer. PMID: 29032338
22. In patients with gastric cancer, the positive-to-negative conversion of the Snail status-between primary tumors and lymph node metastasis may be important for confirming epithelial-mesenchymal transition and mesenchymal-epithelial transition. PMID: 28247164
23. Inhibition of cell migration, invasion, and metastasis in esophageal carcinoma requires CBX8-mediated repression of Snail. PMID: 28912889
24. Dermal fibroblast-to-myofibroblast transition sustained by alphavss3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. PMID: 29309923
25. increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development PMID: 28939076
26. FoxM1 may enhance the invasion and migration of cancer cells, and thus promotes their Epithelialmesenchymal transition, in a mechanism that may involve the regulation of Snai1. PMID: 28849004
27. High SNAIL expression is associated with invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer. PMID: 28424413
28. Twist1 and Snail1 expression levels were associated with lymphovascular space invasion, lymph node metastasis and histological grade in cervical squamous cell carcinoma. PMID: 29101499
29. Data show that miR-153 was found to target the 3'-UTR of snail transcription factors (Snail) mRNA. PMID: 28459992
30. VEGFA and Snail-1 induction by meningitic Escherichia coli mediates disruption of the blood-brain barrier PMID: 27588479
31. miR-199a-5p inhibited the progression of PTC by downregulating SNAI1, offering new insight into the molecular mechanism underlying PTC progression. PMID: 29427661
32. our results suggest that Cx32 inhibits Hepatocellular carcinoma (HCC) invasion and metastasis through Snail-mediated EMT, Cx32 and this signaling pathway molecules may offer potential targets for HCC cancer therapy PMID: 28498415
33. RND3 promotes Snail 1 protein degradation in glioblastoma tumor cells, promoting cell migration and neoplasm invasiveness. PMID: 27705942
34. this study shows that EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells PMID: 27829223
35. SNAI1 is a direct and functional target of miR-182. However SNAI1 negatively regulates the expression of miR-182 in breast cancer cells. PMID: 27894095
36. E-cadherin expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail and p300 expressions in lung cancer. Moreover, p300 acetylates Snail both in vivo and in vitro, and K187 may be involved in this modification. PMID: 28296173
37. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
38. Results show that Snai1 binds to the PXDN promoter in response to TGF-beta1 treatment of cervical carcinoma cell lines and represses its expression. PMID: 29305973
39. increased Snail expression during progression to metastatic disease may prime cells for resistance to AR-targeted therapies by promoting AR activity in prostate cancer PMID: 27409172
40. Snail1 may be a co-factor of TERT enhancer rs2853677 for predicting lung adenocarcinoma susceptibility and prognosis PMID: 27191258
41. Snail-1 might play an important role in the progression of bladder cancer PMID: 27322434
42. Study demonstrated in human breast cancer samples that MDM2 induces epithelial-to-mesenchymal transition by enhancing Snail expression in vitro and in vivo. PMID: 27184007
43. Amla extract (Emblica officinalis, AE) decreases the gene and protein expression of IGF1R, a target of miR-375, and SNAIL1, a transcription factor that represses E-cadherin expression. PMID: 27129171
44. The results demonstrate that knockdown of Snail can inhibit the inhibits epithelial-mesenchymal transition process of laryngeal squamous cell carcinoma cells through the vitamin D receptor signaling pathway in vitro. PMID: 28806534
45. By repressing FOXA family members, SNAIL1 targets transcription factors at strategically important positions in gene-regulatory hierarchies, which may facilitate transcriptional reprogramming during EMT. PMID: 29155818
46. Results show that Snail is a direct target of miR-137 and miR-34a in ovarian cancer cells. PMID: 27596137
47. Results show that Snail1 transcriptional activation is regulated by SOX3 via binding to its promoter region in osteosarcoma cells promoting migration, invasiveness, and EMT. PMID: 28335789
48. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
49. Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells PMID: 28648644
50. There was a significant stepwise increase of upgrading rate according to Snail1 expression in DCIS cells: weak 9%, intermediate 26%, and strong 55%, respectively. PMID: 28570750

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HGNC: 11128

OMIM: 604238

KEGG: hsa:6615

STRING: 9606.ENSP00000244050

UniGene: Hs.48029