Phospho-WASF1 (Tyr125) Antibody

1. Results from a study on gene expression variability markers in early-stage human embryos shows that WASF1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1/Bcl-2 and Beclin1/PI3K- complex-dependent pathways. PMID: 27035872
3. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex. PMID: 26977009
4. we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients PMID: 25906751
5. a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration PMID: 25799492
6. A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta production PMID: 26280122
7. D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation. PMID: 24819384
8. WAVE1 has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain. PMID: 25473116
9. The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells. PMID: 25355952
10. WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in epithelial ovarian cancer. PMID: 23680521
11. Scar/WAVE regulatory complex and N-WASP play opposing roles in 3D epithelial cell migration PMID: 23273897
12. mRNAs encoding structural and regulatory components of the WAVE complex are localized to the leading edge of the cell, suggesting that localized protein synthesis plays a pivotal role in controlling cell spreading and migration. PMID: 23452202
13. Study finds that WAVE1 overexpression is associated with an unfavorable prognosis. WAVE1 is an independent prognostic factor for EOC, which suggests that it is a novel and crucial predictor for EOC metastasis. PMID: 22721732
14. mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia. PMID: 22179776
15. Arf GTPases may be central components in WAVE signalling, acting directly, alongside Rac1. PMID: 21844371
16. WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2. PMID: 19731823
17. Higher levels of WAVE1 in the bone marrow indicate an unfavorable prognosis in children with AML. PMID: 20426950
18. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex PMID: 20368433
19. WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. PMID: 19890377
20. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck: we propose that Rac1 and Nck cause dissociation of the WAVE1 complex, which releases active WAVE1-HSPC300 and leads to actin nucleation. PMID: 12181570
21. WAVE1 may act as a scaffold to recruit the NADPH oxidase to a complex involved with both cytoskeletal regulation and downstream JNK activation PMID: 12855698
22. the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets PMID: 15280206
23. Dictyostelium discoideum has been used to remove genetically SCAR complex members to ascertain their specific roles. PMID: 15506982
24. WAVE-1 expression was associated with megakaryocytic differentiation; WAVE-1 and WAVE-2 moved from a detergent-soluble cytosolic fraction to insoluble cytoskeleton fraction after platelet aggregation PMID: 15670045
25. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl. PMID: 17101133
26. the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil PMID: 17696648
27. WAVE1 is critical for formation of oligodendrocyte lamellae and myelin sheaths--REVIEW PMID: 17901257
28. WAVE1 is involved in multi-drug resistance through regulation the level of mdrl and Bcl-2. PMID: 17939402
29. WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and dendritic spine morphogenesis. PMID: 18287015
30. Results suggest that WAVE and the Arp2/3 complex jointly orchestrate different types of actin-based plasma membrane protrusions by promoting ruffling and inhibiting mDia2-induced filopodia. PMID: 18516090
31. The WAVE1 expression increased in children with ALL. WAVE1 may be related to the development of ALL and may be severed as a marker for the evaluation of the severity of ALL in children. PMID: 18947485
32. WAVE1 and p22phox expression in PBMCs increased and was associated with the disease course in children with acute lymphocytic leukemia (ALL). PMID: 19222940
33. WAVE accumulation may be involved in Abeta/amyloid precursor protein mediated-tangle modification PMID: 19497998

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HGNC: 12732

OMIM: 605035

KEGG: hsa:8936

STRING: 9606.ENSP00000352425

UniGene: Hs.75850