Phospho-XIAP (S87) Antibody

Datasheet
Code CSB-PA009303
Size US$167
Uniprot No. P98170
Image
  • Western Blot analysis of HepG2 cells using Phospho-XIAP (S87) Polyclonal Antibody
Immunogen Synthesized peptide derived from Human XIAP around the phosphorylation site of S87.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias XIAP; API3; BIRC4; IAP3; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked I
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names XIAP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include
Involvement in disease Lymphoproliferative syndrome, X-linked, 2 (XLP2)
Subcellular Location Cytoplasm, Nucleus
Protein Families IAP family
Tissue Specificity Ubiquitous, except peripheral blood leukocytes.
Database Links

HGNC: 592

OMIM: 300079

KEGG: hsa:331

STRING: 9606.ENSP00000347858

UniGene: Hs.356076

Pathway Focal adhesion
NF-kappa B signaling pathway
Apoptosis
Necroptosis
Ubiquitin mediated proteolysis
NOD-like receptor signaling pathway

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