Phospho-XIAP (Ser87) Antibody

Datasheet
Code CSB-PA548634
Product Type Polyclonal Antibody
Size US$360
Uniprot No. P98170
Image
  • Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) antibody.The lane on the right is treated with the antigen-specific peptide.
Immunogen Peptide sequence around phosphorylation site of serine87(K-V-S(p)-P-N) derived from Human XIAP .
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of XIAP only when phosphorylated at serine 87.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.

Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Clonality Polyclonal
Alias API3; BIR4; BIRC4; IAP3; X-linked IAP
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names XIAP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include
Involvement in disease Lymphoproliferative syndrome, X-linked, 2 (XLP2)
Subcellular Location Cytoplasm, Nucleus
Protein Families IAP family
Tissue Specificity Ubiquitous, except peripheral blood leukocytes.
Database Links

HGNC: 592

OMIM: 300079

KEGG: hsa:331

STRING: 9606.ENSP00000347858

UniGene: Hs.356076

Pathway Focal adhesion
NF-kappa B signaling pathway
Apoptosis
Necroptosis
Ubiquitin mediated proteolysis
NOD-like receptor signaling pathway

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