RAB18 Antibody

Datasheet

Code	CSB-PA878835ESR1HU
Size	US$166
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Image	Western blot All lanes: RAB18 antibody at 0.88µg/ml Lane 1: HepG2 whole cell lysate Lane 2: PC-3 whole cell lysate Lane 3: A375 whole cell lysate Lane 4: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 23, 27, 16 kDa Observed band size: 23 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA878835ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA878835ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB18 Polyclonal antibody

Uniprot No.

Q9NP72

Target Names

RAB18

Alternative Names

AA959686 antibody; RAB18 antibody; RAB18 small GTPase antibody; RAB18; member RAS oncogene family antibody; RAB18_HUMAN antibody; RAB18LI1 antibody; Ras related protein Rab 18 antibody; Ras-asssociated protein RAB18 antibody; Ras-related protein Rab-18 antibody; RP11-148B2.1 antibody; WARBM3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras-related protein Rab-18 protein (1-206AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.

Gene References into Functions

The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
High RAB18 expression is associated with glioma. PMID: 24477653
Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
analysis of a novel splice variant of human Rab18 gene PMID: 16147880
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721

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Involvement in disease

Warburg micro syndrome 3 (WARBM3)

Subcellular Location

Apical cell membrane. Lipid droplet.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 14244

OMIM: 602207

KEGG: hsa:22931

STRING: 9606.ENSP00000349415

UniGene: Hs.406799

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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